Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Media Release - $17M Centre to Boost Creative Industries - February 2009.pdf
, 2015 Media release from the Department of Innovation, Industry, Science, Research and Tertiary Education announcing the Creative Industries Innovation Centre, the $17M centre created to help boost the creative industries in ...
Department of Innovation, Industry, Science, Research and Tertiary Education
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The effect of employee mindfulness in the new media industry on innovative behavior: The chain mediating role of positive emotion and work engagement. [PDF]
Front Psychol, 2022 Kuang TY, Hu Y, Lu Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Discovering University Engagement and Social Media Interaction on Twitter.
, 2018 Having deeply changed our communicating way, nowadays social media represent one of the most transformative challenge both within and outside organizations (Aral, Dellarocas & Godes, 2013). They also provide a vibrant space for universities: informally,
Maddalena della Volpe +1 more
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The Brisbane Media Map: Connecting Students, Industry, and University through Authentic Learning
, 2006 How can an undergraduate course and its technology-integrated learning design strengthen the student-university-industry triad? This paper describes the Brisbane Media Map, (http://bmm.qut.edu.au), an authentic learning project in which undergraduate ...
Christy Collis, Collis, Christy
core +1 more source
The steps that young people and suicide prevention professionals think the social media industry and policymakers should take to improve online safety. A nested cross-sectional study within a Delphi consensus approach. [PDF]
Front Child Adolesc Psychiatry, 2023 Robinson J +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Co-regulation, video-on-demand, and the legal status of audio-visual media [PDF]
, 2010 Media regulation in the United Kingdom has traditionally seen a division between State regulation (in the case of broadcasting) and self-regulation (in the case of newspapers), both subject to laws of general application.
Daith Mac Sthigh, Mac Sithigh, Daithi
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source