Results 41 to 50 of about 406,763 (291)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Evaluating ESL classroom evaluation: teacher–student beliefs and teacher practices in Sunyani East Municipality, Ghana

Discover Education
Given the important role of evaluation in the language-learning classroom, understanding its application in a particular context is crucial for improving language learning outcomes.
Gorden Naandung Feikaab, Francis Bukari, Emmanuel Lauren Oblie   +2 more
doaj   +1 more source

Exploiting Prosody for Syntactic Analysis in Automatic Speech Understanding

Journal of Language Modelling, 2012
The relation between syntax and prosody is evident, even if the prosodic structure cannot be directly mapped to the syntactic one and vice versa. Syntax-to-prosody mapping is widely used in text-tospeech applications, but prosody-to-syntax mapping is ...
György Szaszák, András Beke
doaj   +1 more source

APPLICATION OF PERFORMATIVE CONCEPT ON ENGLISH LEGAL DOCUMENTS: A STUDY OF PRAGMATICS [PDF]

, 2015
The legal documents contain statements binding between several parties involved in the issues listed in the document. Prenuptial agreement, power of attorney to a case, insurance payments, inheritance issues are commonly discussed in terms of a legal ...
Amalia, Rosaria Mita, Siti fitriani, Rani   +1 more
core  

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Social media and English language writing performances of a Ghanaian ESL class: The nexus

Cogent Education, 2023
The nexus among social media usage and the English language writing performances of a Ghanaian English as Second Language (ESL) class was investigated in this enquiry.
Ramos Asafo-Adjei, Ronald Osei Mensah, Ernest Kwesi Klu, Enock Swanzy-Impraim   +3 more
doaj   +1 more source

LINGUISTICS OF MODERN GEORGIAN MEDIA

Vectors of Social Sciences, 2021
Modern mass media, as an important means of informing the public, determines people’s consciousness, shapes their interests and determines the mood. It has also successfully incorporated the role of an educator from the very beginning. Thus, the media linguistics plays a special role in spreading the native Georgian language, as well as in raising the ...
openaire   +1 more source

Spaces of Inclusion - An explorative study on needs of refugees and migrants in the domain of media communication and on responses by community media [PDF]

, 2018
COMMIT – Community Media Institute is based in Austria and works in the field of media training and research. COMMIT was commissioned by the Information Society Department of Council of Europe Directorate General of Human Rights and Rule of Law to ...
Bellardi, N., Busch, B., Hassemeer, J., Peissl, H., Scifo, Salvatore   +4 more
core  

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Linguistics and the New Media

, 2014
This chapter explores the question how linguistics has reacted to the new media and how our field of study has turned them into an object of study. In the introduction we first explain what linguists explore in general and how they can study language use within the new media, using the methodological possibilities for linguistics that the digital ...
Lorenza Mondada,, Miriam A. Locher
openaire   +2 more sources