Results 61 to 70 of about 921,016 (308)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The importance of social media for management of SMEs [PDF]

, 2022
The aim of this paper is to present new scientific results concerning social media in relation to the SME segment. The empirical research based on a sample of 1,520 respondents from the business sector of the V4 countries provided interesting findings ...
Dvorský, Ján, Amoah, John, Belás, Jaroslav, Šuleř, Petr   +3 more
core  

The Study of the Dimensions of Media and Information Literacy in the Formal and Public Education System of the Country [PDF]

Religion & Communication, 2019
The Ministry of Education is one of the most formal educational institutions in the country and has a substantial role as a source of social development.
Seyed Mahdi Sharifee, Sajjad Karami Namivandi   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Selling Rooms Online: The Use of Social Media and Online Travel Agents

, 2014
Purpose – This paper aims to focus on the reason why hoteliers choose to be present in online travel agent (OTA) and social media web sites for sales purposes.
Masiero L., Inversini, A, Inversini A., Masiero, Lorenzo, Masiero, L, Inversini, Alessandro   +5 more
core   +1 more source

Zarządzanie mediami sportowymi = Sports media management [PDF]

, 2014
Streszczenie Nie jest tajemnicą, że rozwojowi sportu sprzyja utrzymywanie dobrych relacji z mediami. Na rynku istnieje wiele branżowych kanałów telewizyjnych i internetowych, programów radiowych czy prasy, poświęconych aktywności fizycznej ...
Pawlak, Gabriel, Tomanek, Mateusz, Malinowski, Łukasz   +2 more
core   +1 more source

Factores que facilitan la generación de ‘engagement’ con programas de televisión: exploración cualitativa desde la identidad del canal, las características del producto y la valoración de las audiencias

Estudios sobre el Mensaje Periodístico, 2017
La presente investigación principalmente cualitativa buscó conocer qué elementos de la identidad del Canal RCN afectan la exposición y por consiguiente la generación de compromiso por parte de las audiencias.
Manuel Ignacio González Bernal, Sergio Roncallo Dow, Enrique Uribe-Jongbloed, Germán Arango-Forero   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Media Management: The Attention Perspective

Zarządzanie Mediami, 2022
With media being one of the first sectors of the information economy to be fully (i.e. with respect to its design, production, distribution, and consumption) digitized, an era of its management has come to an end. Existing boundaries between different media types have collapsed, as well as all limitations about time and space of media dissemination ...
Bohdan Jung, Tadeusz Kowalski
openaire   +2 more sources