Results 231 to 240 of about 19,289,864 (307)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Encephalitic alphavirus infection induces long-term humoral and cell-mediated responses in seropositive participants from Panama. [PDF]

PLoS Negl Trop Dis
Cohen CA, Carrera JP, Galué J, Beltran D, Corrales R, Rivera LF, Chaverra Z, Suarez Y, Marciaga J, Rock ML, Ha MC, Wetzel DL, O'Brien EV, Abelson D, Bornholdt ZA, Moyer CL, Zeitlin L, Pascale JM, Dye JM, López-Vergés S, Herbert AS.   +20 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

A clinical trial of cognitive behavioral interventions for social media addiction, psychological problems, quality of family relationships and academic performance among university students. [PDF]

Discov Ment Health
Abbas Q, Iftekhar I, Riaz A, Kareem A, Maryam R, Tabassum U, Abu-AlKhair F, Aljhani S.   +7 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Digital distraction and adolescent development: a narrative review of smartphone use, cognitive effects, and policy interventions. [PDF]

Front Psychol
Colakoglu D, van Golen C.
europepmc   +1 more source

The "Perfect Trip" on social media: strategic self-presentation in travel sharing, posting anxiety, and retrospective trip satisfaction with social comparison orientation as a moderator. [PDF]

Front Psychol
Zheng W, Wang X, Chen X, Weng W.
europepmc   +1 more source