Results 51 to 60 of about 1,258,697 (314)

New Media and Fat Democracy: The Paradox of Online Participation

, 2010
This piece speculates on the internet’s wider influences on the shape of institutional politics in representative ‘actually existing democracies’. Findings, based on 100 semi-structured interviews with political actors (politicians, journalists and ...
Davis, Aeron
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

How a moderated online discussion forum facilitates support for young people with eating disorders [PDF]

, 2016
Introduction: Eating disorders in young people can be harmful to social, emotional and physical development and life chances. Young people with eating disorders encounter particular barriers to help-seeking.
Elvey, Rebecca, Pryjmachuk, Steven, Catchpole, R, Sue Kirk, Steven Pryjmachuk, Elvey, R, Sarah Kendal, Catchpole, Roger, Pryjmachuk, Steven; id_orcid, Rebecca Elvey, Kirk, Sue, Kendal, S, Pryjmachuk, S, Kendal, Sarah, Roger Catchpole, Kirk, Susan, Kirk, S   +16 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

UPAYA PERAN MEDIA MULTIMEDIA DALAM PENYAMPAIAN INFORMASI JURNALISTIK DI MEDIA ONLINE OKEZONE.COM

Jurnal Ilmiah Dinamika Sosial
Jurnalisme online menggantikan televisi, radio, dan surat kabar sebagai sumber informasi utama. Penelitian ini mengkaji pentingnya multimedia dalam jurnalisme Okezone.com. Penggunaan media pada platform dan dampaknya terhadap penyampaian informasi kepada
Rahman Siregar, Muhammad Yoserizal Saragih   +1 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

News Media Credibility comparative between Internet and Television in Jordan [PDF]

المجلة المصرية لبحوث الإعلام, 2018
In this study, a survey design was used to determine the factors influences the perception of media credibility in Jordanian societies to decipher how respondents perceive the Internet and television in terms of credibility for news information. A survey
Maged El Khodary
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Development of Online Learning Media by Using Moodle for General Chemistry Subject

Journal of EST (Educational Science And Technology), 2020
This study aims to develop and obtain eligible online learning media by using moodle for general chemistry subjects by using moodle. In this study, flash animation and simulation were integrated as online media in moodle to attract students’ motivation ...
Asyti Febliza, Oktariani Okatariani
doaj   +1 more source