Results 81 to 90 of about 46,124,642 (306)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

“I Don’t Care About Politics, I Just Like That Guy!” Affective Disposition and Political Attributes in Information Processing of Political Talk Shows

open access: yesInternational Journal of Communication, 2017
Drawing on the affect infusion model and on affective disposition theory, this study aims to explain the influence of viewers’ affective disposition toward the guests of political TV talk shows on their information processing and judgments.
Carina Weinmann   +6 more
doaj   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Big AI: Cloud infrastructure dependence and the industrialisation of artificial intelligence

open access: yesBig Data & Society
Critical scholars contend that ‘There is no AI without Big Tech’. This study delves into the substantial role played by major technology conglomerates, including Amazon, Microsoft, and Google (Alphabet), in the ‘industrialisation of artificial ...
Fernando van der Vlist   +2 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Criticism of the Police in the News

open access: yesNordicom Review, 2014
Mediated descriptions of reality are tremendously important to the way the public - and policymakers - perceive the police. The present article analyses how leading news outlets reported and commented on complaints against the Norwegian police during the
Pollack Ester, Allern Sigurd
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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