Results 81 to 90 of about 50,670,518 (386)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Teenagers, screens and social media: a narrative review of reviews and key studies

Social Psychiatry and Psychiatric Epidemiology, 2020
Introduction In light of growing concerns about an increasingly digital adolescence, the academic field investigating how digital technologies affect adolescents’ psychological well-being is growing rapidly.
Amy C. Orben
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Mediating urban politics [PDF]

, 2009
Despite the turn to relational vocabularies in urban theory, most work on urban politics acknowledging the importance of media has tended to reproduce a centred image of ‘the media’ and a functionalist account of mediation.
Amin, Barnett, Berland, Couldry, Couldry, Couldry, Falkheimer, Fritzsche, Graham, Isin, Iveson, Massey, Moore, Morley, Reckwitz, Scannell, Schatzki, Schatzki, Scott, Shove, Sieverts, Silverstone   +21 more
core   +3 more sources

Role of Epidemiological Studies in Disease Prevention [PDF]

, 2019
Today's society is full of disease that are of different natures including genetic, infectious and metabolic etc. Every disease has its own mechanisms of affecting humans and different prevention mechanisms as per disease nature.
Akthar, M. S. (Muhammad)
core  

Wet Granular Materials

, 2006
Most studies on granular physics have focused on dry granular media, with no liquids between the grains. However, in geology and many real world applications (e.g., food processing, pharmaceuticals, ceramics, civil engineering, constructions, and many ...
Albert I, Albert R, Bagnold RA, Bartelt P, Baumann G, Behringer RP, Benza VG, Bonamy D, Bowden FP, Cassel DK, Castellanos A, Cates ME, Coniglio A, Coussot P, Crassous J, D'Anna G, D'Anna G, D'Anna G, D'Anna G, de Gennes P-G, Dikau R, Duran J, Ertas D, Fierro A, Forsyth AJ, Franco Nori, Fraysse N, Fukue M, Geromichalos D, Gioia G, Géminard J-C, Hakuno M, Herminghaus S, Hertz H, Hilf JW, Ho DYF, Hornbaker DJ, Israelachvili JN, Kansai International Airport Co. Ltd., Kimura Y, Knight JB, Kristensen HG, Kudrolli A, Kézdi Á, Landau LD, Lian G, Liu AJ, Losert W, Lu N, Makse HA, Mason TG, Medved M, Melo F, Mitarai N, Mitarai N, Mitarai N, Mitarai N, Namiko Mitarai, Nase ST, Nasuno S, Nedderman RM, Newitt DM, Nicodemi M, Nicodemi M, Nicor F, Nori F, Nowak S, Oka F, Olivi-Tran N, Pak HK, Phene CJ, Phene CJ, Pierrat P, Pinkus O, Pitois O, Pöschel T, Rajchenbach J, Rajchenbach J, Reed JS, Renard S, Restagno F, Ristow GH, Ristow GH, Schell M, Schulz M, Seligman G, Shapiro LH, Tarjus G, Tegzes P, Tegzes P, Tegzes P, Van Damme H, Xu H, Xu JQ   +93 more
core   +3 more sources

Experimental studies of phase conjugation with depleted pumps in photorefractive media [PDF]

, 1985
We describe the experimental measurement of phase-conjugate reflectivity versus various ratios of input-beam intensities in photorefractive barium titanate and strontium barium niobate crystals.
Chung, Young-Hoon, Cronin-Golomb, Mark, Kwong, Sze-Keung, Yariv, Amnon   +3 more
core   +1 more source

Why “intergenerational feminist media studies”?

An Intergenerational Feminist Media Studies, 2016
Feminism and generation are live and ideologically freighted issues that are subject to a substantial amount of media engagement. The figure of the millennial and the baby boomer, for example, regularly circulate in mainstream media, often accompanied by
Alison Winch, J. Littler, J. Keller
semanticscholar   +1 more source