Results 81 to 90 of about 6,239,559 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

“I Don’t Care About Politics, I Just Like That Guy!” Affective Disposition and Political Attributes in Information Processing of Political Talk Shows

International Journal of Communication, 2017
Drawing on the affect infusion model and on affective disposition theory, this study aims to explain the influence of viewers’ affective disposition toward the guests of political TV talk shows on their information processing and judgments.
Carina Weinmann, Franziska S. Roth, Frank M. Schneider, Tanja Krämer, Frederic R. Hopp, Melanie J. Bindl, Arlene Luck   +6 more
doaj   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Criticism of the Police in the News

Nordicom Review, 2014
Mediated descriptions of reality are tremendously important to the way the public - and policymakers - perceive the police. The present article analyses how leading news outlets reported and commented on complaints against the Norwegian police during the
Pollack Ester, Allern Sigurd
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ultra-Slow Light and Enhanced Nonlinear Optical Effects in a Coherently Driven Hot Atomic Gas

, 1999
We report the observation of small group velocities of order 90 meters per second, and large group delays of greater than 0.26 ms, in an optically dense hot rubidium gas (~360 K).
A. Imamoğlu, A. Kasapi, Alexander S. Zibrov, D. J. Gauthier, Edward S. Fry, George R. Welch, H. Schmidt, L. Hollberg, L. V. Hau, M. D. Lukin, M. D. Lukin, M. D. Lukin, M. Dunstan, M. Jain, M. O. Scully, Marlan O. Scully, Michael M. Kash, Mikhail D. Lukin, O. Schmidt, S. Brandt, S. E. Harris, S. E. Harris, Vladimir A. Sautenkov, Yuri Rostovtsev   +23 more
core   +1 more source

Social Media and it\u27s Effects on Mental Health of High School Students [PDF]

, 2020
Previous studies have established a link between mental health and social media usage. That research has shown that social media usage in students can be detrimental to their self-esteem, motivation, and generalized anxiety.
Brandy, Emma, Engel, Nancy, Mullins, Kimberly   +2 more
core   +1 more source

Mediating urban politics [PDF]

, 2009
Despite the turn to relational vocabularies in urban theory, most work on urban politics acknowledging the importance of media has tended to reproduce a centred image of ‘the media’ and a functionalist account of mediation.
Amin, Barnett, Berland, Couldry, Couldry, Couldry, Falkheimer, Fritzsche, Graham, Isin, Iveson, Massey, Moore, Morley, Reckwitz, Scannell, Schatzki, Schatzki, Scott, Shove, Sieverts, Silverstone   +21 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source