Results 91 to 100 of about 18,480,642 (305)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Sustainability Initiatives Conference Outline

open access: yes, 2001
The outline is a concept for a Sustainability initiative conference that would allow interested parties to share their initiatives in the area of sustainability.
Sustainability Council of Venura County
core  

The Role of the Use of Social Media Marketing in Achieve Business Sustainability [PDF]

open access: yes
Based on the results of a survey conducted by the Central Statistics Agency in 2019, from the 3,504 block census, 15.08% of perpetrators undertook activity through the Internet.
SHIRATINA, Aldina   +2 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

A Model to Identify Affordances for Game-Based Sustainability Learning [PDF]

open access: yes
Sustainability learning requires the assimilation of domain-specific knowledge and the development of mindsets suitable to engage in complex system dynamics to foster sustainable action.
López, Ximena, Fabricatore, Carlo
core   +3 more sources

Science for change: A survey on the normative and political dimensions of global sustainability research [PDF]

open access: yes, 2018
Global change and sustainability research increasingly focusses on informing and shaping societal transformations towards more sustainable futures. Doing so, researchers encounter the deeply political and normative dimensions of sustainability problems ...
Global Sustainability Governance   +2 more
core   +1 more source

The Sustainability of Local Media Within the Domination of National Media Industry

open access: yesE3S Web of Conferences, 2018
Indonesia’s current condition on regional and policy still show inequality between the Java and other regions, such as in the West and East Indonesia. The gap is also apparent in the context of media, where in various regions in Indonesia, the dominance ...
Maryani Eni   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Web for sustainability: tackling environmental complexity with scale

open access: yes
There are contrasting ways to understand the Web: as global technical infrastructure, the largest ever information construct, and as social new media. Existing communities of ICT for sustainability, such as environmental informatics, Green ICT, and even ...
Townsend, Jack H.
core   +1 more source

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