Results 61 to 70 of about 18,480,642 (305)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Determinants of sustainability and organisational effectiveness in non-profit organisations

, 2015
This case study investigates the criteria for organizational effectiveness in non-profit organizations (NPOs) with the aim to determine how the elements of sustainability fit within the criteria. To achieve this, the study utilized the research questions:
Kapondoro, Lloyd, Tengeh, Robertson, Robertson Tengeh, Lloyd Kapondoro, Twum-Darko, Michael, Chux Iwu, Michael Twum-Darko, Iwu, Chux Gervase, Twum-Darko, Dr Michael, Tengeh, Robertson Khan   +9 more
core   +1 more source

Sustainability Advocacy Antecedents: how Social Media Content Influences Sustainable Behaviours among Generation Z

International Journal of Business, Economics, and Social Development
This study examines how sustainable habits and sustainable consumption behaviors influence the discussion of exposure to sustainability content on social media and the sustainability advocacy on social media.
Dyah Permata Sari, Adi Setiawan
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Social Media-Based Educational Guidelines on Academic Nursing Students' Performance regarding Sustainability Development [PDF]

Egyptian Journal of Health Care
Background: A multifaceted idea, sustainability awareness includes information, attitudes, and actions about environmental, social, and economic issues.
Noha Mohamed Rashed, Gehan Awad Shetaway, Manal Abd Elsalam Amin, Asmaa Mohamed Ahmed Maiz   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fusing non-textual cues with classical NLP for enhanced multimodal fake news spread detection

Scientific Reports
The increasing spread of misinformation on social platforms has made it necessary to develop automated and accurate fake news detection systems. Traditional methods that focus solely on textual content are ineffective in dealing with more complex fake ...
Jing Dang, Yichen Sun, Chengzhi Yu
doaj   +1 more source

Model Determining the Success of Sustainability Report Disclosure in Indonesia

Riset Akuntansi dan Keuangan Indonesia
This study aims to analyze the effect of profitability, leverage, liquidity, company size, corporate governance, environmental performance, and media exposure on sustainability reports.
Triyono, Fatchan Achyani, Sandy Prasetyo, Lamin Khaira   +3 more
doaj   +1 more source

Visualizing and gamifying consumption data for resource saving: challenges, lessons learnt and a research agenda for the future

Energy Informatics, 2019
In this paper we present insights drawn from recent research projects aimed at developing visualization and gamification tools to stimulate individual behaviour change and promote energy and water saving.
Piero Fraternali, Francesca Cellina, Sergio Luis Herrera Gonzales, Mark Melenhorst, Jasminko Novak, Chiara Pasini, Cristina Rottondi, Andrea Emilio Rizzoli   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source