Results 31 to 40 of about 16,710 (245)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Investigating Learners’ Technology Engagement - A Perspective From Ubiquitous Game-Based Learning in Smart Campus

IEEE Access, 2018
With the increasing development of information technology and emerging of modern mobile devices, researchers have been shedding light on the integration of ubiquitous learning and online games in the construction of smart campus, aiming to enhance the ...
Xuesong Zhai, Yan Dong, Jing Yuan
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Designing and explaining the persuasiveness model in social media messages in promoting green products [PDF]

رویکرد‌های نوین در مدیریت و بازاریابی
The main objective of this research is to design and explain the conceptual model of persuasiveness in social media messages for promoting green products.
Mosa mohsenpour, Nasser Fegh-hi Farahmand, Hossein Gharehbiglo, Hossein Bodaghi Khajeh Noubar   +3 more
doaj   +1 more source

Analisis Kasus Ketergantungan Manusia Terhadap Media Digital dalam Media System Dependency Theory

Social Empirical
Kemampuan literasi digital masyarakat Indonesia meningkat seiring dengan berkembangnya teknologi informasi dan komunikasi yang ditandai dengan makin tingginya jumlah pengguna smartphone dan akses internet dalam kehidupan sehari-hari. Saat ini jumlah pengguna yang aktif di media sosial yang ada di Indonesia mencapai 191 juta orang pada Januari 2022 ...
Luthfiyyah Rahayu, null Muhammad Rizky, null AB Sarca Putera, null Ayu Adriyani   +3 more
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Rasch validation of a new scale to measure dependency in arm use in daily life: the Upper Limb Lucerne ICF-based Multidisciplinary Observation Scale. [PDF]

, 2023
INTRODUCTION About 77% of adults with stroke have upper limb impairments. Many scales are available to measure the impairment and activity level of the affected limb.
Ottiger, Beatrice, Veerbeek, Janne Marieke, Vanbellingen, Tim, Nyffeler, Thomas, Van de Winckel, Ann   +4 more
core   +1 more source

Cartography of Biopower in the Digital Age: Crisis of the Nation-states in the Field of Biodata Forces [PDF]

دولت‌پژوهی
IntroductionThe state, as the central institution organizing collective life, fundamentally possesses a monopoly on legitimate authority and territorial sovereignty within a defined realm. This concept rests on three pillars: sovereignty as the exclusive
Sajjad Omidoiur
doaj   +1 more source