Results 71 to 80 of about 16,710 (245)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2015 While enterprise social media (ESM) increasingly plays a vital role in improving teamwork in organizations, our understanding of how ESM is used by team members is still limited.
Chen, Xiayu +2 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Value-framing abortion in the United States: An application of media system depency theory
, 1990 This paper is in the tradition of social analysis aimed at creating frameworks to join mass media and public opinion processes (e.g. COMPONENTS OF MEDIA SYSTEM DEPENDENCY THEORY MSD theory is a theory in progress.
S Jf Ball-Rokeach +4 more
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2015 This thesis investigates the capacity of the newly introduced Chinese Special Economic Zones in Africa (CSEZAs) to deliver ‘cooperation’ and ‘mutual development’ to China and Africa.
Cowaloosur, Honita
core
, 2020 The problematic use of mobile social networking apps (SNAs) is an increasing issue in various places where people live and work. For example, employees’ use of mobile SNAs at work can result in significant loss of productivity.
Lin, X., Wang, T., Wang, X., Liu, Z.
core
, 2017 Using smartphones for day-to-day working practices is now common for employees working in many organizations and companies. This dissertation is among the first to apply Media System Dependency (MSD) theory to understand smartphone dependency within a ...
Li, Li
core +1 more source