Results 71 to 80 of about 569,016 (270)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The AMIGA sample of isolated galaxies XI. A First Look at Isolated Galaxy Colors

, 2012
The basic properties of galaxies can be affected by both nature (internal processes) or nurture (interactions and effects of environment). Deconvolving the two effects is an important current effort in astrophysics.
Aihara, Athanassoula, Baillard, Baldry, Baldry, Ball, Balogh, Blanton, Blanton, Blanton, Bottinelli, Bruzual, Calzetti, Capak, Dressler, Durbala, Espada, Fouque, Gunn, Heidmann, Hogg, Hogg, Iovino, J. E. Ruiz, J. Sabater, J. Sulentic, Karachentsev, Karachentseva, L. Verdes-Montenegro, Larson, Leon, Leon, Lewis, Lisenfeld, Lisenfeld, M. Fernández Lorenzo, Marcum, Masters, Nair, Patton, Paturel, Paturel, Reid, S. Sánchez, Sabater, Schlegel, Schmidt, Skibba, Stocke, Strateva, Sulentic, Sulentic, van der Wel, van der Wel, Verdes-Montenegro, Verley, Verley, Xu, York   +58 more
core   +1 more source

What accuracy statistics really measure [PDF]

, 2001
Provides the software estimation research community with a better understanding of the meaning of, and relationship between, two statistics that are often used to assess the accuracy of predictive models: the mean magnitude relative error (MMRE) and the ...
B.A. Kitchenham, JORGENSEN, L.M. Pickard, LO, M.J. Shepperd, MIYAZAKI, MYRTVEIT, PICKARD, S.G. MacDonell, STENSRUD   +9 more
core   +1 more source

Median Absolute Deviation to Improve Hit Selection for Genome-Scale RNAi Screens

SLAS Discovery, 2008
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small dynamic ranges and significant variability because of the combination of cellular heterogeneity, transfection efficiency, and the
Namjin, Chung, Xiaohua Douglas, Zhang, Anthony, Kreamer, Louis, Locco, Pei-Fen, Kuan, Steven, Bartz, Peter S, Linsley, Marc, Ferrer, Berta, Strulovici   +8 more
openaire   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

An enhanced adaptive non-local means algorithm for Rician noise reduction in magnetic resonance brain images

BMC Medical Imaging, 2020
Background The Rician noise formed in magnetic resonance (MR) imaging greatly reduced the accuracy and reliability of subsequent analysis, and most of the existing denoising methods are suitable for Gaussian noise rather than Rician noise.
Kaixin Chen, Xiao Lin, Xing Hu, Jiayao Wang, Han Zhong, Linhua Jiang   +5 more
doaj   +1 more source

The Effect of Median Based Estimators on CUSUM Chart [PDF]

, 2018
Cumulative Sum (CUSUM) chart has been used extensively to monitor mean shifts.It is highly sought after by practitioners and researchers in many areas of quality control due to its sensitivity in detecting small to moderate shifts.
Abdul Rahman, Ayu, Atta, Abdu Mohammed Ali, Syed Yahaya, Sharipah Soaad   +2 more
core  

Near-infrared observations of type Ia supernovae: The best known standard candle for cosmology [PDF]

, 2012
We present an analysis of the Hubble diagram for 12 Type Ia supernovae (SNe Ia) observed in the near-infrared J and H bands. We select SNe exclusively from the redshift range 0.03 < z < 0.09 to reduce uncertainties coming from peculiar velocities while ...
A. Gal-Yam, Alard, Bronder, C. Lidman, Casali, Conley, Conley, D. A. Howell, D. Poznanski, D. Xu, E. Ofek, E. Y. Hsiao, Folatelli, Hodapp, Hsiao, I. Arcavi, I. M. Hook, J. Cooke, J. Mould, J. S. B. Wyithe, Jha, K. Maguire, Kasen, Krisciunas, Law, M. M. Kasliwal, M. Sullivan, Mandel, Mandel, Meikle, P. E. Nugent, Persson, Phillips, R. L. Barone-Nugent, Rau, S. B. Cenko, Smith, Sullivan, Tripp, Walker, Wood-Vasey   +40 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The massive star population of the Virgo Cluster galaxy NGC 4535

, 2018
We analyzed the massive star population of the Virgo Cluster galaxy NGC 4535 using archival Hubble Space Telescope Wide Field Planetary Camera 2 images in filters F555W and F814W, equivalent to Johnson V and Kron-Cousins I.
Bellas-Velidis, I., Bonanos, A. Z., Gavras, P., Hatzidimitriou, D., Kopsacheili, M., Kourniotis, M., Lianou, S., Moretti, M. I., Nota, A., Pouliasis, E., Sokolovsky, K. V., Spetsieri, Z. T., Yang, M.   +12 more
core   +1 more source