Results 41 to 50 of about 37,129 (261)

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Birth conditions affect the longevity of Holstein offspring

Journal of Dairy Science, 2022
: Studies of dairy cow longevity usually focus on the animal life after first calving, with few studies considering early life conditions and their effects on longevity.
Gabriel M. Dallago, Roger I. Cue, Kevin M. Wade, René Lacroix, Elsa Vasseur   +4 more
doaj   +1 more source

Implementation of MAD and Mean Absolute Deviation based Smoothing Algorithm for Displacement Data in Digital Image Correlation Technique [PDF]

, 2014
This study aims at obtaining smoothed strain fields from digital image correlation technique (DIC), by smoothing the displacement fields prior to strain computation.
Harilal, R, M, Ramji, Paul, K J
core  

Two nonparametric approaches to mean absolute deviation portfolio selection model

Journal of Industrial and Management Optimization, 2020
In this paper, we apply two nonparametric approaches to mean absolute deviation (MAD) portfolio selection model. The first one is to use the nonparametric kernel mean estimation to replace the returns of assets with five different kernel functions. Then,
Zhifeng Dai, Huan Zhu, Fenghua Wen
semanticscholar   +1 more source

Unidirectional Tape‐Based Composites from Hemp and Pineapple Leaf Fiber: Mechanical Performance in Conventional and Bio‐Based Matrices

Advanced Engineering Materials, EarlyView.
The study investigates novel semi‐finished products made of unidirectionally arranged hemp or pineapple leaf fiber‐reinforced composites produced from different matrices. The materials are analyzed in terms of their mechanical and interfacial properties and void content.
Nina Graupner, Raja Bade, Valentin Ackermann, Roja M. Baumann, Corvin Bischoff, Jona F. Ebeling, Oskar Glenz, Marlo Groh, Jonathan Groth, Finja Hiller, Tom Hirschmüller, Felix Menke, Syntcha Ngantchou Lecdou, Mika Ohler, Daniel Rafii Vardiny, Darius Richter, Dario Röper, Henrik Schumacher, Theresa Stein, Benjamin Vorbeck, Elisabeth Wermter, Kay Kölzig, Jörg Müssig   +22 more
wiley   +1 more source

Ice Sheet Topography from a New CryoSat-2 SARIn Processing Chain, and Assessment by Comparison to ICESat-2 over Antarctica

Remote Sensing, 2021
In this study, we present a new level-2 processing chain dedicated to the CryoSat-2 Synthetic Aperture Radar Interferometric (SARIn) measurements acquired over ice sheets.
Jérémie Aublanc, Pierre Thibaut, Amandine Guillot, François Boy, Nicolas Picot   +4 more
doaj   +1 more source

Modified Repeated Median Filters [PDF]

, 2004
We discuss moving window techniques for fast extraction of a signal comprising monotonic trends and abrupt shifts from a noisy time series with irrelevant spikes.
Bernholt, Thorsten, Fried, Roland, Gather, Ursula, Wegener, Ingo   +3 more
core   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Comparison of isotopic mass balance and instrumental techniques as estimates of basin hydrology in seven connected lakes over 12 years

Journal of Hydrology X, 2020
Mass-balance models using stable isotopes of hydrogen and oxygen provide useful estimates of the water balance of lakes, particularly in the absence of instrumental data.
H.A. Haig, N.M. Hayes, G.L. Simpson, Y. Yi, B. Wissel, K.R. Hodder, P.R. Leavitt   +6 more
doaj   +1 more source

Implementing and Characterizing Real-time Broadband RFI Excision for the GMRT Wideband Backend

, 2017
The Giant Metrewave Radio Telescope (GMRT) is being upgraded to increase the receiver sensitivity. This makes the receiver more susceptible to man-made Radio Frequency Interference (RFI).
Ajithkumar, B, Bhatporia, Shruti, Buch, Kaushal D., Gupta, Yashwant, Naik, Kishor, Nalawade, Swapnil   +5 more
core   +1 more source