Results 161 to 170 of about 18,907,323 (361)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Mediating Effect of Vitamin D on the Association Between Exercise and Triglyceride in Adolescents: A Prospective Cross-sectional Study

Xiehe Yixue Zazhi
ObjectiveTo investigate the mediating role of vitamin D in the association between exerciseand triglyceride among adolescents, as well as its potential molecular mechanisms.MethodsThis prospective cross-sectional study utilized convenience sampling ...
HUANG Bochuan, GUO Xiaoyuan, WANG Yutong, LIU Jiaxuan, PAN Hui, CHEN Shi   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Activities of daily living mediate the association between balance and falls in middle aged and older adults

Scientific Reports
Falls constitute a significant public health issue affecting middle-aged and older adults.The consequences of falls extend beyond physical injuries and compromised quality of life to encompass psychological and socioeconomic dimensions.
Jiaran Jiang, Quan Zhou, Chuanxia Zhang, Keer Cong   +3 more
doaj   +1 more source

The impact of the sports industry on the development of the health industry: an exploration of mediating and threshold effects

Frontiers in Public Health
IntroductionThe sports and health industries play a crucial role in fulfilling individuals' aspirations for an enhanced quality of life and in supporting the development of a Healthy China.MethodsTo explore the impact mechanism of the sports industry ...
Shutong Zhao, Shutong Zhao, Haiyan Huang
doaj   +1 more source

Hubungan Etika Profesi, Keahlian, Pengalaman, dan Situasi Audit dengan Ketepatan Pemberian Opini dalam Audit Laporan Keuangan melalui Pertimbangan Materialitas dan Skeptisisme Profesional Auditor [PDF]

, 2014
This research is to examine the relation between ethics, expertise, experience, and audit situation with accuracy of the issuing of audit opinion through materiality judgment and auditors professional scepticism as a mediating effect.
DP, E. N. (Emrinaldi), Saidi, J. (Julita), Wahyudi, D. P. (Dwi)   +2 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mediating effect of self-coping mechanisms on associations between financial practices and financial security of female-headed households [PDF]

, 2016
Coping process involves contingency actions of individual to alter their cognitive and behaviour to cope with stress encountering events in life. Self-coping mechanisms were examined further as mediating effect between financial practices and financial ...
Abdul Rahim @ Abdul Wahab, Husniyah, Ahmad, Siti Yuliandi, Osman, Syuhaily, Sabri, Mohamad Fazli   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source