Results 181 to 190 of about 1,930,794 (341)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

, 2019
Tzu-Chi Chen, Jian‐Ying Chuang, Chiung-Yuan Ko, Tzu‐Jen Kao, Pei-Yu Yang, Chun-Hui Yu, Mingsheng Liu, Siou-Lian Hu, Yu-Ting Tsai, Hardy Chan, Wen‐Chang Chang, Tsung‐I Hsu   +11 more
openalex   +1 more source

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty [PDF]

, 2020
Violeta Heras, Juan M. Castellano, Daniela Fernandois, Inmaculada Velasco, Elvira Rodríguez-Vázquez, Juan Roa, María J. Vázquez, Francisco Ruíz-Pino, Matias Rubio, Rafael Pineda, Encarnación Torres, María Soledad Avendaño, Alfonso Paredes, Leonor Pinilla, Denise D. Belsham, Carlos Diéguez, Francisco Gaytán, Núria Casals, Miguel López, Manuel Tena‐Sempere   +19 more
openalex   +1 more source

General Control of Amino Acid Synthesis 5‐Like 1‐Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease [PDF]

, 2021
Tingting Lv, Yao Lu, Yi Liu, Hong Feng, Chensheng Li, Sheng Wei, Zheng‐Guo Cui, Suwei Zhu, Xia Gu, Zhe Yang, Qiang Wan   +10 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-α secretion in plasmacytoid dendritic cells

, 2007
Elena Martinelli, Claudia Cicala, Donald Van Ryk, Diana Goode, Katilyn Macleod, James Arthos, Anthony S. Fauci   +6 more
openalex   +1 more source

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation [PDF]

, 2021
Liang Hong, Meihong Zhang, Olivia T Ly, Hanna Chen, Arvind Sridhar, Erin Lambers, Brandon Chalazan, Seock‐Won Youn, Mark Maienschein‐Cline, Leonid Feferman, Sang‐Ging Ong, Joseph C. Wu, Jalees Rehman, Dawood Darbar   +13 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

David Dean Shulman. Tamil: A Biography. pp. 416. The Belknap Press of Harvard University Press, Cambridge, Massachusetts,and London 2016, ISBN 978-0674059924. $ 35 / £ 28.95 / € 31.50

Cracow Indological Studies, 2020
Olga Vecherina
doaj   +1 more source