Results 201 to 210 of about 1,894,725 (339)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Depression and social connectedness as mechanisms linking frailty to quality of life in older African migrants in Australia. [PDF]

NPJ Aging
Dzando G, Ward PR, Mwanri L, Agbadi P, Ambagtsheer RC.   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Electrophysiological resting-state signatures link polygenic scores to general intelligence. [PDF]

Sci Rep
Engler R, Stammen C, Arnau S, Schneider Penate J, Metzen D, Digutsch J, Gajewski PD, Getzmann S, Fraenz C, Reinders J, Voelkle MC, Streit F, Ocklenburg S, Schneider D, Burke M, Hengstler JG, Watzl C, Nitsche MA, Kumsta R, Wascher E, Genç E.   +20 more
europepmc   +1 more source

ORE1 balances leaf senescence against maintenance by antagonizing G2‐like‐mediated transcription

, 2013
Mamoona Rauf, Muhammad Arif, Hakan Dortay, Lilian P. Matallana-Ramirez, Mark T. Waters, Hong Gil Nam, Pyung‐Ok Lim, Bernd Mueller‐Roeber, Salma Balazadeh   +8 more
openalex   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Adverse childhood experiences, basic psychological needs, and adolescent affective distress: Revisiting the buffering role of resilience factors. [PDF]

J Res Adolesc
Zhou K, Zhu X, Lu C, Yang Y, Chen S.
europepmc   +1 more source

The CD44‐Mediated Uptake of Hyaluronic Acid‐Based Carriers in Macrophages

, 2016
Julio M. Rios De La Rosa, Annalisa Tirella, Arianna Gennari, Ian J. Stratford, Nicola Tirelli   +4 more
openalex   +2 more sources

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Multiomics Integration of Epigenetics, Proteomics, and Metabolomics Identifies Putative Drug Targets and Improves Early Prediction for Diabetes. [PDF]

Diabetes
Li W, Cheng Y, Cui A, Huang M, Huang Q, Wang Q, Xia M, Qiu J, Peng Q, Li J, Li H, Wang Y, Zong G, Zheng Y, Wang J, Gao X, Ding C, Tang H, Jiang BH, Jin L, Li Y, Wang S.   +21 more
europepmc   +1 more source