Results 201 to 210 of about 1,930,794 (341)

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation [PDF]

, 2017
Alessandro Fantin, Αναστασία Λαμπροπούλου, Valentina Senatore, James T. Brash, Claudia Prahst, Clemens Lange, Sidath E. Liyanage, Claudio Raimondi, James Bainbridge, Hellmut G. Augustin, Christiana Ruhrberg   +10 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Powerful large scale inference in high dimensional mediation analysis. [PDF]

PLoS Comput Biol
Roy A, Zhang X.
europepmc   +1 more source

Mediation design [PDF]

, 2020
Gottardi, Piero, Mezzetti, Claudio
core  

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre‐synaptic mechanism(s): implications to manganese‐induced parkinsonism

, 2008
Tomás R. Guilarte, Thomas Sardella, Jennifer L. McGlothan, Tatyana Verina, Yun Zhou, Mohab Alexander, Luu Pham, Michael Griswold, Dean F. Wong, Tore Syversen, Jay S. Schneider   +10 more
openalex   +2 more sources

Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch

, 2021
Yue Deng, Shuangyue Li, Zhenzhen Chen, Wenjie Wang, Bin Geng, Jun Cai   +5 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Applications of Medical Mediation: A Systematic Review of Its Role in Healthcare Dispute Resolution and Bioethical Decision-Making. [PDF]

Healthcare (Basel)
Lioupi O, Kostoulas P, Griva K, Billinis C, Tsiamis C.   +4 more
europepmc   +1 more source

Endophyte-Mediated Modulation of Defense-Related Genes and Systemic Resistance in Withania somnifera (L.) Dunal under Alternaria alternata Stress [PDF]

, 2018
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, Chandra Shekhar Nautiyal   +6 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source