Results 211 to 220 of about 1,760,545 (309)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study. [PDF]

Open Med (Wars)
Chen L, Yi Y, Zhu Y.
europepmc   +1 more source

Episome-mediated Transfer of Drug Resistance in Enterobacteriaceae X. Restriction and Modification of Phages by fi− R Factors

, 1966
Tsutomu Watanabe, Toshiya Takano, Toshihiko Arai, Hiroshi Nishida, Sachiko Sato   +4 more
openalex   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Correction: Gender moderates the mediating effect of psychological capital between physical activity and depressive symptoms among adolescents. [PDF]

Sci Rep
Luo X, Liu H, Sun Z, Wei Q, Zhang J, Zhang T, Liu Y.   +6 more
europepmc   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

The Reciprocal Relationship Between Parental eHealth Literacy Mediation and Adolescents' eHealth Literacy: Three-Wave Longitudinal Study.

J Med Internet Res
Tercova N, Muzik M, Dedkova L, Smahel D.
europepmc   +1 more source

Effects of age at first separation from parents on suicidal ideation, suicide planning and suicide attempts among left-behind children: the causal mediating effect of traumatic events. [PDF]

Fam Med Community Health
Wu X, Zhai X, Wang J, Liu Y, Wu Y, Huang Y, Zhou M, Xiang B, Yang M, Xie X, Zeng J.   +10 more
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Pathways Linking ICT Use to Chronic Disease Self-Management Among Older Adults with Comorbidities in Shanghai, China. [PDF]

Healthcare (Basel)
Chen Q, Gong K, Bao Z, Yin Y, Zhao L, Chen YY.   +5 more
europepmc   +1 more source