Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Parenting Style and Child Internet Addiction in China: Mediation Effect of Parental Active Meditation. [PDF]
Int J Environ Res Public HealthLiu SW, Chen S, Huang C, Vallario J.
europepmc +1 more source
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Exploring Patient Awareness and the Feasibility of Mediation in Healthcare: A Pilot Study in Bulgaria. [PDF]
Healthcare (Basel)Dimitrov KY, Miteva-Katrandzhieva T.
europepmc +1 more source
Mediation of Delayed Hypersensitivity by Peripheral Blood Lymphocytes in Vitro and by Their Products in Vivo and in Vitro, Morphology of in Vitro Lymphocyte-Macrophage Interaction [PDF]
, 1968 Harry Bartfeld, Robert L. Kelly
openalex +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy. [PDF]
BioData MinXu H +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Attachment in Young Adults With Chronic Pain: The Mediating Role of Cognitive Appraisals in the Relationship Between Attachment Security, Pain Coping and Functioning. [PDF]
Eur J PainHarte N +4 more
europepmc +1 more source
Mediation of Phytochrome in the Inductive Action of Low Temperature on Dark Germination of Lettuce Seed at Supra-Optimal Temperature [PDF]
, 1966 Nurit Roth‐Bejerano +2 more
openalex +1 more source