Results 211 to 220 of about 1,930,794 (341)

Causal Mediation Analysis of the Effects of Pain Education on Disability and Pain Intensity in Individuals with Chronic Low Back Pain. [PDF]

J Clin Med
Alalawi A.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peak strain dispersion as a nonlinear mediator in HFpEF: Unraveling subtype-specific pathways via SHAP-augmented ensemble modeling. [PDF]

PLoS Comput Biol
Lin M, Li K, Wang X, Sun J, Gong K, Wang Z, Sun P.   +6 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluating Methods for High-Dimensional Mediation in Metabolomics Data. [PDF]

Environ Sci Technol
Hoffman SS, Liang D, Dunlop A, Everson T, Gaskins AJ, Jones DP, Hüls A, Marcus M, Naimi AI.   +8 more
europepmc   +1 more source

Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice

, 2010
Renata Kobayasi, Eliana Hiromi Akamine, Ana Paula Davel, Maria Aparecida Marchesan Rodrigues, Carla Roberta de Oliveira Carvalho, Luciana Venturini Rossoni   +5 more
openalex   +1 more source

OsCYP71D8L as a key regulator involved in growth and stress response by mediating gibberellins homeostasis in rice [PDF]

, 2019
Jiahao Zhou, Zeyu Li, Guiqing Xiao, Mingjuan Zhai, Xiaowu Pan, Rongfeng Huang, Haiwen Zhang   +6 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mendelian randomization analysis of immune cell subsets and inflammatory cytokines in aplastic anaemia. [PDF]

Ann Hematol
Hu K, Cheng Y, Xiao G, Shen X, Zhu J, Huang M, Fei Y, Qian S, Shao X.   +8 more
europepmc   +1 more source

Reduced muscle strength in patients with long-COVID-19 syndrome is mediated by limb muscle mass

, 2022
Robinson Ramírez‐Vélez, Gaizka Legarra‐Gorgoñon, Sergio Oscoz-Ochandorena, Yesenia García‐Alonso, Nora García-Alonso, Julio Oteiza, Ander Ernaga Lorea, María Correa‐Rodríguez, Míkel Izquierdo   +8 more
openalex   +2 more sources