Results 221 to 230 of about 1,894,725 (339)

Associations between cyberbullying victimization and cyberbullying: a three-wave longitudinal moderated mediation model. [PDF]

BMC Psychol
Wu J, Gao Y, Xiao Q, Hao Q, Liu Z.
europepmc   +1 more source

Barley Stripe Mosaic Virus-Mediated Tools for Investigating Gene Function in Cereal Plants and Their Pathogens: Virus-Induced Gene Silencing, Host-Mediated Gene Silencing, and Virus-Mediated Overexpression of Heterologous Protein

, 2012
Wing‐Sham Lee, K. E. Hammond‐Kosack, K. Kanyuka   +2 more
openalex   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Inference in group sequential designs with causal mechanisms: implications for power and mediation analysis. [PDF]

BMC Med Res Methodol
Lee KM, Emsley R.
europepmc   +1 more source

The mediated learning experience and the mediator’s implications

, 2005
It is clear that educators can affect learning positively or negatively, that a personal or professional attitude will immediately change the awareness pupils have toward our classes. Furthermore, as educators, we can not encourage in our pupils the development of good cognitive and socioemotional strategies if we do not constitute ourselves as a model
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A novel anti‐inflammatory role for secretory phospholipase A ₂ in immune complex‐mediated arthritis

, 2010
Éric Boilard, Ying Lai, Katherine Larabee, Barbara Balestrieri, Farideh Ghomashchi, Daisuke Fujioka, Reuben Gobezie, Jonathan S. Coblyn, Michael E. Weinblatt, Elena Massarotti, Thomas S. Thornhill, Maziar Divangahi, Heinz G. Remold, Gérard Lambeau, Michael H. Gelb, P. Jonathan, David M. Lee   +16 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Psychological states mediate the relationship between sleep quality and frailty among older adults. [PDF]

Front Psychol
Su H, Wei L, Lin Y, Hu C, Lv Y, Li H, He X, Zhang D, Ni X.   +8 more
europepmc   +1 more source

Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: Computational modelling and preliminary in vivovalidation

, 2012
Astrid Gasselhuber, Matthew R. Dreher, Ari Partanen, Pavel Yarmolenko, David L. Woods, Bradford J. Wood, Dieter Haemmerich   +6 more
openalex   +2 more sources