Results 41 to 50 of about 3,869,309 (345)

Expert Wine Tasting as a Social Practice: An Enactive Ethnography

Sociologica, 2019
The present contribution uses the theoretical framework of theories of practice to examine expert wine tasting. This paper highlights a number of sociologically interesting issues that have been previously conceptualised in the literature, trying to ...
Mario de Benedittis
doaj   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Knowledge Management in Moroccan Public Administration: An Exploratory Study and Recommendations

Journal of Information Sciences
This article highlights the growing importance of knowledge management (KM) as intellectual capital in modern organizations, with a focus on Moroccan public administration. It begins with a literature review of the main theoretical foundations of KM and
Sanae ELKADMIRI, Noureddine ELMQADDEM, Hanane EL YOUSFI   +2 more
doaj   +1 more source

Mediation analysis with graph mediator

Biostatistics
Summary This study introduces a mediation analysis framework when the mediator is a graph. A Gaussian covariance graph model is assumed for graph presentation. Causal estimands and assumptions are discussed under this presentation. With a covariance matrix as the mediator, a low-rank representation is introduced and parametric mediation ...
Yixi Xu, Yi Zhao
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

bioRxiv, 2019
Background Mendelian randomisation uses genetic variants randomly allocated at conception as instrumental variables for a modifiable exposure of interest.
A. Carter, E. Sanderson, G. Hammerton, R. Richmond, G. Davey Smith, J. Heron, Amy E Taylor, N. Davies, L. Howe   +8 more
semanticscholar   +1 more source

Mediation an Schulen [PDF]

Praxis Der Kinderpsychologie Und Kinderpsychiatrie, 2006
Die Leitfragen dieses Beitrags beziehen sich auf Ziele und Auswirkungen der Einführung von Mediation in eine Schulkultur der Dominanz, des Wettbewerbs und der Auswahl. Zusätzlich soll die Notwendigkeit der Verbindung von Konfliktlösung mit Organisationsentwicklung und der Einführung eines ethischen Konsens gezeigt werden, um nachhaltige Ergebnisse in ...
openaire   +3 more sources

Plant mediator [PDF]

Plant Signaling & Behavior, 2010
Jasmonate (JA) signaling plays an important role in regulating both plant defense and development. We have recently reported that the phytochrome and flowering time1 (PFT1) gene, which encodes the mediator25 subunit of the plant Mediator complex, is a key regulator of JA regulated transcription.
Kidd, Brendan N., Aitken, Elizabeth A., Schenk, Peer M., Manners, John M., Kazan, Kemal   +4 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source