Results 51 to 60 of about 4,289,560 (302)

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

open access: yesFEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee   +4 more
wiley   +1 more source

The Yeast Mediator

open access: yesMolecules and Cells, 2001
The large number of signaling pathways and regulatory proteins that affect transcription highlights a need for funneling of information since transcription of all protein encoding genes is executed by the same set of general transcription factors and RNA polymerase II.
Björklund, Stefan   +2 more
openaire   +3 more sources

Two-condition within-participant statistical mediation analysis: A path-analytic framework.

open access: yesPsychological methods, 2017
Researchers interested in testing mediation often use designs where participants are measured on a dependent variable Y and a mediator M in both of 2 different circumstances. The dominant approach to assessing mediation in such a design, proposed by Judd,
A. Montoya, A. Hayes
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard   +7 more
wiley   +1 more source

Court Mediation and the Search for Justice Through Law [PDF]

open access: yes, 1996
The trend toward court mediation is remarkable because our civil justice system has traditionally promised justice through law. The promise of mediation is different: Justice is derived, not through the operation of law, but through autonomy and self ...
Nolan-Haley, Jacqueline
core   +2 more sources

MEDIATION VS. MEDIATOR

open access: yesAgora International Journal of Juridical Sciences, 2013
The title of this paper was suggested by the confusion existing even among certainmediators about what mediation is and what it represents actually.Is mediation “a different type of justice” or, otherwise, it is “an alternative totraditional justice”?
openaire   +3 more sources

Mirror mediation [PDF]

open access: yesJournal of High Energy Physics, 2008
33 pages, 1 figure; v2: typos, references, minor ...
openaire   +3 more sources

Identification, Inference and Sensitivity Analysis for Causal Mediation Effects [PDF]

open access: yes, 2010
Causal mediation analysis is routinely conducted by applied researchers in a variety of disciplines. The goal of such an analysis is to investigate alternative causal mechanisms by examining the roles of intermediate variables that lie in the causal ...
K. Imai, L. Keele, Teppei Yamamoto
semanticscholar   +1 more source

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

open access: yesFEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova   +3 more
wiley   +1 more source

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