Results 61 to 70 of about 4,449,689 (375)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Current Infectious Disease Reports, 2007 During sepsis, the plasma levels of numerous inflammatory markers are enhanced. Some of these markers are the mediators responsible for the syndromes observed during sepsis as well as for organ dysfunction and eventually death. Their role has been demonstrated in experimental models that employed either transgenic and gene-targeted animals or the use ...
Jean-Marc Cavaillon +1 more
openaire +3 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
European Mediation and Indigenous Mediation
Teisė, 2020 The article investigates the European and Indigenous mediation and its different circumstances. Mediation is one of a variety of procedures to solve a conflict; it is based on the voluntary participation of the parties and it is a procedure, in which an intermediary without adjudicatory powers (the mediator) systematically facilitates communication ...
openaire +4 more sources
Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5
FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu +4 more
wiley +1 more source
Bayesian Hierarchical Models for High-Dimensional Mediation Analysis with Coordinated Selection of Correlated Mediators [PDF]
arXiv, 2020 We consider Bayesian high-dimensional mediation analysis to identify among a large set of correlated potential mediators the active ones that mediate the effect from an exposure variable to an outcome of interest. Correlations among mediators are commonly observed in modern data analysis; examples include the activated voxels within connected regions ...
arxiv
Sparse Principal Component based High-Dimensional Mediation Analysis [PDF]
, 2018 Causal mediation analysis aims to quantify the intermediate effect of a mediator on the causal pathway from treatment to outcome. With multiple mediators, which are potentially causally dependent, the possible decomposition of pathway effects grows exponentially with the number of mediators.
arxiv +1 more source
Mapping Perspectives on the EU as Mediator [PDF]
, 2015 Research on the European Union’s role as a meditator is nascent. It predominantly focuses on case studies or is cursorily embedded within wider research on the European Union (EU) as a crisis manager. Moreover, there is a significant disconnect between
Haastrup, Toni
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Testing Mediation Effects Using Logic of Boolean Matrices [PDF]
arXiv, 2020 Mediation analysis is becoming an increasingly important tool in scientific studies. A central question in high-dimensional mediation analysis is to infer the significance of individual mediators. The main challenge is the sheer number of possible paths that go through all combinations of mediators.
arxiv