Results 61 to 70 of about 3,869,309 (345)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Identification, Inference and Sensitivity Analysis for Causal Mediation Effects [PDF]
, 2010 Causal mediation analysis is routinely conducted by applied researchers in a variety of disciplines. The goal of such an analysis is to investigate alternative causal mechanisms by examining the roles of intermediate variables that lie in the causal ...
K. Imai, L. Keele, Teppei Yamamoto
semanticscholar +1 more source
Controlled Mediation as a Generalization of Interventional Mediation [PDF]
Epidemiology, 2019 No abstract available.
openaire +4 more sources
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Media and CommunicationThis article presents qualitative research findings on parents’ digital media practices. Through 32 in-depth interviews with parents of 0–6-year-olds in French-speaking Belgium, the study addresses digital inclusion by exploring the diverse ways parents ...
Caroline Robbeets +6 more
doaj +1 more source
Agora International Journal of Juridical Sciences, 2013 The title of this paper was suggested by the confusion existing even among certainmediators about what mediation is and what it represents actually.Is mediation “a different type of justice” or, otherwise, it is “an alternative totraditional justice”?
openaire +3 more sources
Molecules and Cells, 2001 The large number of signaling pathways and regulatory proteins that affect transcription highlights a need for funneling of information since transcription of all protein encoding genes is executed by the same set of general transcription factors and RNA polymerase II.
Björklund, Stefan +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
Journal of High Energy Physics, 2008 33 pages, 1 figure; v2: typos, references, minor ...
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Causal mediation analysis with a latent mediator [PDF]
Biometrical Journal, 2015 Health researchers are often interested in assessing the direct effect of a treatment or exposure on an outcome variable, as well as its indirect (or mediation) effect through an intermediate variable (or mediator). For an outcome following a nonlinear model, the mediation formula may be used to estimate causally interpretable mediation effects.
Suchitra Nelson +2 more
openaire +3 more sources