Results 61 to 70 of about 3,741,405 (383)
Bayesian Image Mediation Analysis [PDF]
arXiv, 2023 Mediation analysis aims to separate the indirect effect through mediators from the direct effect of the exposure on the outcome. It is challenging to perform mediation analysis with neuroimaging data which involves high dimensionality, complex spatial correlations, sparse activation patterns and relatively low signal-to-noise ratio.
arxiv
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Praxis Der Kinderpsychologie Und Kinderpsychiatrie, 2006 Die Leitfragen dieses Beitrags beziehen sich auf Ziele und Auswirkungen der Einführung von Mediation in eine Schulkultur der Dominanz, des Wettbewerbs und der Auswahl. Zusätzlich soll die Notwendigkeit der Verbindung von Konfliktlösung mit Organisationsentwicklung und der Einführung eines ethischen Konsens gezeigt werden, um nachhaltige Ergebnisse in ...
openaire +3 more sources
Plant Signaling & Behavior, 2010 Jasmonate (JA) signaling plays an important role in regulating both plant defense and development. We have recently reported that the phytochrome and flowering time1 (PFT1) gene, which encodes the mediator25 subunit of the plant Mediator complex, is a key regulator of JA regulated transcription.
Kidd, Brendan N. +4 more
openaire +3 more sources
Mediated Learning Strategies in Families with Children with Disabilities: A Literature Review
Formazione & Insegnamento, 2022 The purpose of this literature review is to identify patterns and to discuss key perspectives from empirical studies published from 2000 until 2021 that explore mediated learning strategies in families with children with disabilities.
Francesca Granone +3 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Current Infectious Disease Reports, 2007 During sepsis, the plasma levels of numerous inflammatory markers are enhanced. Some of these markers are the mediators responsible for the syndromes observed during sepsis as well as for organ dysfunction and eventually death. Their role has been demonstrated in experimental models that employed either transgenic and gene-targeted animals or the use ...
Jean-Marc Cavaillon +1 more
openaire +3 more sources
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Mendelian randomisation for mediation analysis: current methods and challenges for implementation
bioRxiv, 2019 Background Mendelian randomisation uses genetic variants randomly allocated at conception as instrumental variables for a modifiable exposure of interest.
A. Carter +8 more
semanticscholar +1 more source
Divorce and family mediation: an overview
Психология и Психотерапия Семьи, 2017 Emotional tension of family conflicts predetermined the demand for mediation in this area as a more flexible and informal way of resolving disputes, which focuses on the interests of the parties and meeting their psychological needs.
Nikolay Gordiychuk
doaj