Results 61 to 70 of about 1,002,739 (239)

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation [PDF]

, 2010
We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications.
A Birkedal-Hansen, A Birkedal-Hansen, A Brignole, A Brignole, A Falkowski, A Pierce, AH Chamseddine, AJ Barr, B Altunkaynak, Baris Altunkaynak, BC Allanach, Brent D. Nelson, CF Berger, CR Nappi, D Feldman, D Feldman, D Feldman, DE Kaplan, DJH Chung, GF Giudice, GF Giudice, GL Bayatian, H Baer, H Baer, H Baer, H Baer, H Baer, H Baer, H Baer, H Baer, HP Nilles, I Hinchliffe, Ian-Woo Kim, J Alwall, J Alwall, JA Bagger, JG Branson, JL Feng, K Choi, K Choi, K Choi, K Choi, K Choi, K Choi, K Choi, K Choi, K Choi, KJ Bae, L Randall, L Álvarez-Gaumé, Lisa L. Everett, LJ Hall, LL Everett, LL Everett, M Dine, M Dine, M Dine, M Dine, M Dine, M Endo, M Holmes, M Ibe, N Arkani-Hamed, P Langacker, P Langacker, R Barbieri, R Dermisek, R Kitano, S Asai, S Asai, S Dimopoulos, S Dimopoulos, S Kachru, SF King, SK Soni, SP Martin, SP Martin, SP Martin, T Gherghetta, T Sjöstrand, WS Cho, Yongyan Rao, Z Chacko   +82 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Reducing Test Bias Through Dynamic Assessment Of Children's Word Learning Ability [PDF]

, 2001
This study examined the performance of preschool children from culturally and linguistically diverse backgrounds, both typically developing and with low language ability, on a word-learning task.
Iglesias, Aquiles, Lidz, Carol S., Pena, Elizabeth   +2 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

On the Spectrum of Direct Gaugino Mediation

, 2011
In direct gauge mediation, the gaugino masses are anomalously small, giving rise to a split SUSY spectrum. Here we investigate the superpartner spectrum in a minimal version of "direct gaugino mediation." We find that the sfermion masses are comparable ...
A Giveon, A Maloney, A Simone De, Amit Giveon, BC Allanach, C Csáki, D Green, D Marques, DE Kaplan, E Poppitz, HC Cheng, J Bij van der, KA Intriligator, M Buican, M McGarrie, M McGarrie, N Craig, N Seiberg, P Batra, P Meade, R Auzzi, R Auzzi, Roberto Auzzi, S Chatrchyan, S Shirai, SP Martin, Sven Bjarke Gudnason, Tomer Shacham, TT Dumitrescu, Z Chacko, Z Komargodski   +30 more
core   +1 more source

Soft Supersymmetry Breaking in KKLT Flux Compactification [PDF]

, 2005
We examine the structure of soft supersymmetry breaking terms in KKLT models of flux compactification with low energy supersymmetry. Moduli are stabilized by fluxes and nonperturbative dynamics while a de Sitter vacuum is obtained by adding supersymmetry
Choi, Kiwoon, Falkowski, Adam, Nilles, Hans Peter, Olechowski, Marek   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source