Results 121 to 130 of about 9,734,843 (296)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Mediation and your business [PDF]
, 2012 This presentation, delivered to the regional business community at the Kent 20/20 event in April 2012, will provide an overview of the Mediation Clinic project at Canterbury Christ Church University, the first of its kind to be established in a UK ...
Waters, B.
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Some Consideration on the Mediation Contract [PDF]
Interaction between people is the most different and diverse, from harmony to the conflict , so that when conflicts arise between them, because they are bound by a contract, the legal system offers a wide range of possibilities for settlement, the ...
Stoica, Veronica
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MEDIATION OPPORTUNITIES IN CARTEL DAMAGES CLAIMS IN BRAZIL [PDF]
, 2019 The paper discusses the opportunities for the use of mediation in cartel damages claims in Brazil. For this, the paper discusses the growth of the private mediation market in Brazil as well as the art of choosing a consensual dispute resolution method ...
Daniela, Monteiro Gabbay +1 more
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Counterfactual graphical models for longitudinal mediation analysis with unobserved confounding
, 2013 Questions concerning mediated causal effects are of great interest in psychology, cognitive science, medicine, social science, public health, and many other disciplines.
Shpitser, Ilya
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Nonlinear mediation in clustered data : a nonlinear multilevel mediation model [PDF]
, 2013 textMediational analysis quantifies proposed causal mechanisms through which treatments act on outcomes. In the presence of clustered data, conventional multiple regression mediational methods break down, requiring the use of hierarchical linear modeling
Lockhart, Lester Leland
core +1 more source