Results 141 to 150 of about 19,703 (241)

A celebritização da sociedade e da cultura: entendendo a dinâmica estrutural da cultura da celebridade [PDF]

open access: yes, 2014
In recent debates about the ever-growing prominence of celebrity in society and culture, a number of scholars have started to use the often intermingled terms ‘celebrification’ and ‘celebritization’.
Driessens, Olivier
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Policy framework and systems management of global climate change [PDF]

open access: yes
Climate change is representative of a general class of environmental issues where decisions have to be taken under controversies. The policy framework for these kinds of decisions is defined by three important traits: scientific ignorance, mediatization ...
Jean-Charles Hourcade, Minh Ha-Duong
core  

From Watchdog to Watched Dog: Oversight and Pressures between Journalists and Politicians in the Context of Mediatization [PDF]

open access: yes, 2014
Political control is one of the central and conditioning aspects of the relationship between journalists and politicians. Through the perceptions of journalists and politicians, this article analyzes the validity, characteristics, and functioning ...
Casero-Ripollés, Andreu   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

APONTAMENTOS SOBRE MEDIAÇÃO E MIDIATIZAÇÃO: UMA REFLEXÃO SOBRE AS RELAÇÕES IMBRICAS ENTRE MÍDIA, POLÍTICA E SOCIEDADE (NOTES ABOUT MEDIATION AND MEDIATITIZATION: REFLEXION ABOUT RELATION BETWEEN MEDIA, POLITICS AND SOCIETY)

open access: yesEmancipação, 2009
No século XX, os media passam a fazer parte de nossas vidas, não só encurtando o tempo e as distâncias, mas gerando um novo fenômeno que veio a denomina-se mediatização.
Hebe Maria Gonçalves Oliveira
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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