Results 211 to 220 of about 474,197 (261)

Heterogeneous causal mediation analysis using Bayesian additive regression trees. [PDF]

Biometrics
Liu C, Qin X, Talisa VB, Wang J.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploratory Multivariate Analysis of Mediator Organization in Canine Platelet-Rich Gel Under NSAID Exposure. [PDF]

Gels
Carmona JU, Ospina J, López C.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

When MED16 Meets Plant Growth, Development, and Stress Response. [PDF]

Int J Mol Sci
Li L, Qi SL, Shen C, Zhi TT, Zou J, Chen G.   +5 more
europepmc   +1 more source

Mediation for Mediators?

Mediation for Mediators?
openaire  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bovine xanthine oxidase electrocatalysis: substrate oxidation and its role in nitrite reduction. [PDF]

J Biol Inorg Chem
Giang PD, Niks D, Hille R, Bernhardt PV.
europepmc   +1 more source

Similarity of sputum mediator signatures between e-cigarette users and COPD depends on GOLD stage and type of e-cigarette: a pilot study. [PDF]

PLoS One
Hickman E, Dabbs W, Wells H, Barr RG, Woodruff P, Ohar J, Martinez FJ, Bowler R, Cooper CB, Curtis JL, Wells JM, Labaki WW, Jaspers I, Rager JE, Alexis NE.   +14 more
europepmc   +1 more source

A comparison and evaluation of statistical methods for mediation analysis with mixtures of environmental exposures. [PDF]

BMC Med Res Methodol
McGrath S, Wang Y, Lin YT, Meeker JD, Park SK, Warren JL, Mukherjee B.   +6 more
europepmc   +1 more source