Results 91 to 100 of about 4,197,094 (329)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Online Learning, 2019 This study investigates perceived ease of use and overall computer/internet experience as emotional factors that affect e-learning. Results suggest that online learning systems design should address typical software interfaces so that students feel more
Raafat George Saadé, Dennis Kira
doaj +1 more source
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation
Nature reviews. Immunology, 2015 Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty acids and have important roles in orchestrating the resolution of tissue inflammation — that is, catabasis.
M. Basil, B. Levy
semanticscholar +1 more source
Mediating Climate, Mediating Scale [PDF]
Humanities, 2019 Climate communication is seemingly stuck in a double bind. The problem of global warming requires inherently trans-scalar modes of engagement, encompassing times and spaces that exceed local frames of experience and meaning. Climate media must therefore negotiate representational extremes that risk overwhelming their audience with the immensity of the ...
openaire +2 more sources
Siting Power Plants: Recent Experience in California and Best Practices in Other States [PDF]
, 2002 Compares California's power plant siting with results in other states. Includes interviews with California state agency representatives, developers and process mediators.
Paul J. Hibbard, Susan F. Tierney
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Frontiers in Neuroscience, 2018 Past research has demonstrated to the ability of psychedelics to enhance suggestibility, and pointed to their ability to amplify perception of meaning.
Ido Hartogsohn
doaj +1 more source
The role of immune cells and mediators in preeclampsia
Nature Reviews Nephrology, 2023 E. Deer +6 more
semanticscholar +1 more source