Results 81 to 90 of about 1,299,395 (278)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Does Nationality Influence Neutrality? The Ethical Standards and Expectations of International Mediators [PDF]
, 2016 This Comment examines how a mediator’s nationality can influence the mediating parties’ and communities’ perceptions of his neutrality and how cultural differences play a role in the ethical expectations of a cross-cultural mediator. Part I discusses the
Katsoris, Melissa
core +1 more source
Dark Matter Complementarity and the Z$^\prime$ Portal
, 2015 Z' gauge bosons arise in many particle physics models as mediators between the dark and visible sectors. We exploit dark matter complementarity and derive stringent and robust collider, direct and indirect constraints, as well as limits from the muon ...
Alves, Alexandre +3 more
core +1 more source
Mediating Climate, Mediating Scale [PDF]
Humanities, 2019 Climate communication is seemingly stuck in a double bind. The problem of global warming requires inherently trans-scalar modes of engagement, encompassing times and spaces that exceed local frames of experience and meaning. Climate media must therefore negotiate representational extremes that risk overwhelming their audience with the immensity of the ...
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Journal of High Energy Physics, 2013 32 pages, 3 figures, references added, minor ...
Baryakhtar, M +2 more
openaire +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Online Learning, 2019 This study investigates perceived ease of use and overall computer/internet experience as emotional factors that affect e-learning. Results suggest that online learning systems design should address typical software interfaces so that students feel more
Raafat George Saadé, Dennis Kira
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source