Results 61 to 70 of about 314,862 (218)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effectiveness of particulate matter filtration: systematic review and meta-analysis

Revista Brasileira de Enfermagem
Objectives: to assess the effectiveness of filters in filtering particulate matter. Methods: a systematic literature review was conducted with the research question: which filters efficiently adsorb chemical and/or biological particles present in the ...
Francieli Faustino, Helenize Ferreira Lima Leachi, Aline Franco da Rocha, Ana Paula Silva, Rosângela Marion da Silva, Renata Perfeito Ribeiro   +5 more
doaj   +2 more sources

Efficacy and Safety in the Continued Treatment With a Biosimilar Drug in Patients Receiving Infliximab: A Systematic Review in the Context of Decision-Making From a Latin-American Country

Frontiers in Pharmacology, 2019
Introduction: Biological products, including infliximab (INF), are a therapeutic option for various medical conditions. In the Peruvian Social Security (EsSalud), infliximab is approved for the treatment of rheumatoid arthritis, psoriasis, psoriatic ...
Edward Mezones-Holguin, Rocio Violeta Gamboa-Cardenas, Gadwyn Sanchez-Felix, José Chávez-Corrales, Luis Miguel Helguero-Santin, Luis Max Laban Seminario, Paula Alejandra Burela-Prado, Maribel Marilu Castro-Reyes, Fabian Fiestas   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A systematic review of the biomechanical and biological impacts of ultrasound waves on skeletal tissues

BioMedical Engineering OnLine
Introduction Ultrasound waves can affect bone and bone marrow, and widespread medical and industrial use increases the likelihood of direct or indirect exposure.
Amirhossein Montazeri, Mehrana Esnaasharieh, Roohalah Hajizadeh   +2 more
doaj   +1 more source

Biologics in Focus: A Comprehensive Review of Current Biological and Small Molecules Therapies for Crohn’s Disease in the United Arab Emirates (UAE)

Gastrointestinal Disorders
Introduction: The management of Crohn’s disease (CD) in the Middle East, like in other parts of the world, is rapidly evolving with the introduction of novel advanced medical and biological therapies. In the United Arab Emirates (UAE), several biological
Laith Alrubaiy, Louise Christine Pitsillides, Thomas O’Connor, Matilda Woodhill, Harry Higgins, Thaer Khaleel Swaid, Doa’a Alkhader, Zaher Koutoubi   +7 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Identifying the Fungal Health-Threatening Factors for Librarians and Users in Libraries of Isfahan University of Medical Sciences, Iran in 2011

مدیریت اطلاعات سلامت, 2012
Introduction: Fungi are biological threatening which exist in all the environments. Libraries and archive centers are a suitable environment for the growth of fungi. The aim of this study was to identify fungal life-threatening factors for librarians and
Mostafa Chadeganipour, Hossein Rafiee, Rezvan Ojaghi, Seyedeh Tayyebeh Hashemi, Ahmad Papi, Mojtaba Akbari   +5 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source