Results 21 to 30 of about 2,335,008 (261)

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications

Annals of Intensive Care
The understanding of the response to stress in critical illness has significantly improved in recent years. These adaptations unfold across acute, subacute, and chronic phases, with an early adaptive catabolic state, marked anabolic resistance, and a ...
Raphael Mottale, Claire Dupuis, Sylwia Szklarzewska, Jean-Charles Preiser   +3 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Neuromuscular blockade and their monitoring in the intensive care unit: a multicenter observational prospective study

Annals of Intensive Care
Background: Neuromuscular blocking agents may improve outcomes in specific conditions, including the early phase of acute respiratory distress syndrome.
Bertrand Hermann, Guillaume Decormeille, Tiphanie Gobé, Nathanaël Mangeard, Adel Maamar, Saria Sayadi, Bénédicte Pernod, Nadine Robquin, Jean-Pierre Ponthus, Sophie Le Potier, Pierre Bouju, Angélique Balabanian, Antoine Frouin, Sébastien Moschietto, Gwenaelle Jacq, Emeline Villemont, Clémence Houbé, Anaïs Queyreau, Célina Morand, Florence Boissier, Jean-Baptiste Lascarrou, Sabine Valera, Sami Hraiech, Laure Clouet, Gaël Piton, Cindérella Noël, Anne Joosten, Cécilia Tabra Osorio, Adrien Constan, Jérôme Cecchini, Gwennaelle Mercier, Arnaud Bruyneel, Chloé Villamaux, François Pousset, Nicholas Heming, Laurent Poiroux, Jean-François Llitjos, Saber Davide Barbar   +37 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Endotoxin removal by the OXIRIS filter for cardiogenic shock requiring veno-arterial extra-corporeal life support: the ECMORIX randomized controlled trial

Annals of Intensive Care
Background: Most severe cardiogenic shock requires veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The OXIRIS filter, has shown potential in reducing lipopolysaccharide (LPS) levels.
Maxime Nguyen, Marvin Alvarez, Corentin Evezard, Vivien Berthoud, Damien Leleu, Jean-Paul Pais-De-Barros, Olivier Bouchot, Osama Abou-Arab, Belaid Bouhemad, David Masson, Thomas Gautier, Pierre-Grégoire Guinot   +11 more
doaj   +1 more source

Improving Transitions of Care: Designing a Blockchain Application for Patient Identity Management

Blockchain in Healthcare Today, 2022
The annual ConV2X is a leading international health tech symposium driving real world evidence, strategy, research, operations and trends to create a blueprint for a new digital health era.
Mustafa Abdul-Moheeth. MD, Texas A&M Health Science Center College of Medicine, Daniel Toshio Harrell, PhD - Research Associate, Dell Medical School at the University of Texas at Austin, Anjum Khurshid, MD, PhD, Director, Data Integration, Co-Chief, Health Information and Data Analytic Sciences, Assistant Professor of Population Health, Affiliate Faculty, Center for Health Communication, Dell Medical School and The University of Texas   +2 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Transplant-free survival in acute liver failure patients receiving MARS®, plasma exchange or no liver support. A real-life 21-year retrospective cohort study in a referral center

Annals of Intensive Care
Background: Whether Molecular Adsorbent Recirculating System (MARS) dialysis and high-volume plasma exchange (HVPE) may improve survival in acute liver failure (ALF) remains unclear.
Kieran Pinceaux, Félicie Bélicard, Valentin Coirier, Estelle Le Pabic, Pauline Guillot, Flora Delamaire, Benoît Painvin, Quentin Quelven, Mathieu Lesouhaitier, Adel Maamar, Arnaud Gacouin, Pauline Houssel-Debry, Karim Boudjema, Edouard Bardou-Jacquet, Jean-Marc Tadié, Florian Reizine, Christophe Camus   +16 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source