Results 81 to 90 of about 94,048 (260)

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

American Dog Tick, Dermacentor variabilis (Say) (Arachnida: Ixodida: Ixodidae)

EDIS, 2009
EENY-443, a 7-page fact sheet by Wai-Han Chan and Phillip E. Kaufman, is part of the Featured Creatures Collection. It describes this tick commonly found on dogs as an adult — its distribution, description, life cycle, seasonality, medical and ...
Wai-Han Chan, Phillip E. Kaufman
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

An annotated wing interferential pattern dataset of dipteran insects of medical interest for deep learning

Scientific Data
Several Diptera species are known to transmit pathogens of medical and veterinary interest. However, identifying these species using conventional methods can be time-consuming, labor-intensive, or expensive.
Arnaud Cannet, Camille Simon-chane, Aymeric Histace, Mohammad Akhoundi, Olivier Romain, Marc Souchaud, Pierre Jacob, Darian Sereno, Philippe Bousses, Denis Sereno   +9 more
doaj   +1 more source

Psorophora columbiae (Dyar & Knab), Dark rice field mosquito

EDIS, 2020
Organism fact sheet for the mosquito, Psorophora columbiae (Dyar & Knab). Fact sheet includes a general overview of the organism, synonymy in nomenclature, current known US distribution, descriptions, life cycle, biology, medical/veterinary importance ...
Christopher Stephen Bibbs, Derrick Mathias, Nathan Daniel Burkett-Cadena   +2 more
doaj  

DEXAMETHASONE USES IN HUMANS AND ANIMALS: PUBLIC HEALTH AND SOCIO-ECONOMIC IMPLICATIONS [PDF]

Kanem Journal of Medical Sciences, 2017
The importance of dexamethasone is demonstrated by its wide uses in human and veterinary medical practice. Unfortunately, dexamethasone use is prone to abuse.
Dauda Yahi, Haruna Nggada, Nicholas A. Ojo, Mohammed B. Mahre, Nanacha A. Igbokwe, Bukar Umaru, Gideon. D. Mshelia   +6 more
doaj  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Seroprevalence of infectious pathogens of zoonotic and veterinary importance in wild ruminants from Slovenia

Frontiers in Veterinary Science
Introduction Wildlife represents an increasingly important source of pathogens of medical and veterinary importance. Surveillance in wildlife offers an insight on current epidemiological status of selected pathogens and help to prevent spillovers to ...
Diana Žele Vengušt, B. Krt, R. Blagus, G. Vengušt, Petra Bandelj   +4 more
semanticscholar   +1 more source