Results 221 to 230 of about 647,370 (315)

A Qualitative Analysis of Underexplored Barriers to Physicians Seeking Mental Health Care in Medical License Applications. [PDF]

J Grad Med Educ
Barrett E, Hicks K, Hunt L, Saddawi-Konefka D.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Artificial intelligence for optimization of immunotherapy: current applications and transformative potential. [PDF]

Front Immunol
Tarhini A, Dave P, Pilon-Thomas S, El Naqa I.   +3 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

In Reply to Sengul I and Sengul D. [PDF]

Adv Radiat Oncol
Dennstädt F, Hastings J, Putora PM, Vu E, Fischer G, Süveg K, Glatzer M, Riggenbach E, Hà HL, Cihoric N.   +9 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Development of a digitalised complex intervention to promote activity of older people in rural areas: study protocol of a feasibility study. [PDF]

Pilot Feasibility Stud
Beutner K, Lamprecht J, Roggendorf S, Aßmann P, Hübner G, Steckelberg A, Schmidt H.   +6 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Developing general practitioner and consumer supports for genomics in Australian primary care: a mixed-methods protocol. [PDF]

BMJ Open
Long JC, Archibald AD, Lamprell K, Dawson-McClaren B, Kraan C, Springer A, Dive L, Newson AJ, Watts G, Holmes I, Cutler H, Jeet V, Trainer A, Best S, Delatycki M, Kirk EP, Laing N, Ferrie M, Freeman L, Willcock S, Spanos S, Gilkes L, Cini J, Edwards S, Leibowitz R, Mahadeva J, Foo D, Churruca K, Patel R, Braithwaite J.   +29 more
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source