Results 161 to 170 of about 2,543,913 (259)

Integration of medical assistance in dying into family practice. [PDF]

Can Fam Physician
Trouton K.
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Correction: For, against, and beyond: healthcare professionals' positions on medical assistance in dying in Spain. [PDF]

BMC Med Ethics
Parra Jounou I, Triviño-Caballero R, Cruz-Piqueras M.   +2 more
europepmc   +1 more source

Response to Medical Assistance in Dying, Palliative Care, Safety, and Structural Vulnerability. [PDF]

J Palliat Med, 2023
Gallagher R, Coelho R, Violette PD, Gaind KS, Chochinov HM.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The moral web of accessibility to medical assistance in dying: Reflections from the Canadian context. [PDF]

Nurs Ethics
Pesut B, Thorne S.
europepmc   +1 more source

Graduate medical education tool kit for the Supplemental Offer and Acceptance Program: Navigating the National Resident Matching Program supplemental offer assistance program

, 2021
Steve Vance, Bethany Figg, Mary Jo Wagner   +2 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Demographic influences on Lithuanian physicians' attitudes toward medical assistance in dying: a cross-sectional study. [PDF]

Front Psychiatry
Bachmetjev B, Airapetian A, Jakubauskienė M, Zablockis R, Čekanauskaitė A.   +4 more
europepmc   +1 more source

P009: Medical assistance in dying – a survey of Canadian emergency physicians [PDF]

, 2019
Francis Bakewell
openalex   +1 more source