Results 201 to 210 of about 2,537,684 (277)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

What Factors Influence Canadian Nurse Practitioners' Willingness to Act as Assessors and Providers for Medical Assistance in Dying (MAID)? [PDF]

Glob Qual Nurs Res
Mokosak Z, Pesut B, Thorne S.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Requests for Medical Assistance in Dying by Young Dutch People With Psychiatric Disorders.

JAMA Psychiatry
Schweren LJS, Rasing SPA, Kammeraat M, Middelkoop LA, Werner R, Mérelle SYM, Garcia JM, Creemers DHM, van Veen SMP.   +8 more
europepmc   +1 more source

Medical assistance in dying: A reflection tool for pharmacists. [PDF]

Can Pharm J (Ott)
Navarrete J, Gray M, King MA, Mey A, Woods P, Schindel TJ.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Does the charitable medical assistance program impact catastrophic medical expenditures for families of children with leukemia? An evidence-based study in China. [PDF]

Int J Equity Health
Su J, Zhang YQ, Shao D, Wang JM, Hao W, Liu YX, Wang L, Sun XJ.   +7 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

International Comparison of Underlying Disease Among Recipients of Medical Assistance in Dying.

JAMA Intern Med
Heidinger B, Webber C, Chambaere K, Close E, Deliens L, Onwuteaka-Philipsen B, Pope T, van der Heide A, White B, Downar J.   +9 more
europepmc   +1 more source

Physicians' moral distinctions between medical assistance in dying (MAiD) and withdrawing life-sustaining treatment in Canada: a qualitative descriptive study. [PDF]

BMC Med Ethics
Matthew M, Bonner K, Stumpf A.
europepmc   +1 more source