Results 231 to 240 of about 1,195,720 (290)

Canada's Medical Assistance in Dying System can Enable Healthcare Serial Killing. [PDF]

HEC Forum
Lyon C.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Requests for Medical Assistance in Dying by Young Dutch People With Psychiatric Disorders.

JAMA Psychiatry
Schweren LJS, Rasing SPA, Kammeraat M, Middelkoop LA, Werner R, Mérelle SYM, Garcia JM, Creemers DHM, van Veen SMP.   +8 more
europepmc   +1 more source

What Factors Influence Canadian Nurse Practitioners' Willingness to Act as Assessors and Providers for Medical Assistance in Dying (MAID)? [PDF]

Glob Qual Nurs Res
Mokosak Z, Pesut B, Thorne S.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Does the charitable medical assistance program impact catastrophic medical expenditures for families of children with leukemia? An evidence-based study in China. [PDF]

Int J Equity Health
Su J, Zhang YQ, Shao D, Wang JM, Hao W, Liu YX, Wang L, Sun XJ.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

International Comparison of Underlying Disease Among Recipients of Medical Assistance in Dying.

JAMA Intern Med
Heidinger B, Webber C, Chambaere K, Close E, Deliens L, Onwuteaka-Philipsen B, Pope T, van der Heide A, White B, Downar J.   +9 more
europepmc   +1 more source

Physicians' moral distinctions between medical assistance in dying (MAiD) and withdrawing life-sustaining treatment in Canada: a qualitative descriptive study. [PDF]

BMC Med Ethics
Matthew M, Bonner K, Stumpf A.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source