Results 81 to 90 of about 2,537,684 (277)

LATE DIAGNOSIS OF HEREDITARY HEMORRHEGIC TELANGIECTASIA

Hematology, Transfusion and Cell Therapy
Introduction: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disease with an average prevalence of 1 in 5000-8000 inhabitants. It is caused by an alteration in angiogenesis that leads to vascular alterations.
NLL Dornelles, RM Quijano, YC Technician, J Ferrari   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

JUSTIFICATION OF THE MANAGEMENT MODEL OF MEDICAL CARE TO PATIENTS WITH OPTIC ATROPHY

Ukrainian Scientific Medical Youth Journal, 2015
Summary. The number of patients with visual impairment in the world is growing steadily. Among the serious ophthalmic disabling diseases special place occupies optic nerve atrophy (ANA).
V. Vasyuta
doaj  

Mortalidade infantil pós-neonatal e qualidade da assistência médica: um estudo caso-controle Postneonatal infant mortality and quality of medical care: a case-control study

Jornal de Pediatria, 2001
OBJETIVOS: identificar os fatores de risco para a mortalidade infantil pós-neonatal por diarréia e pneumonia relacionados à qualidade da assistência médica.
Antônio P. Caldeira, Elizabeth França, Eugênio M.A. Goulart   +2 more
doaj   +1 more source

Virginia\u27s Money Follows the Person Demonstration [PDF]

, 2009
Educational Objectives 1. Describe Virginia\u27s Money Follows the Person Demonstration project, including the new services available to individuals through Virginia\u27s Medicaid-funded home and community-based waiver program. 2.
Lawson, Karen, Rachel, Jason A.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Em contato com a violência: os profissionais de saúde e seus pacientes vítimas de maus tratos En contacto con la violencia: los profesionales de la salud y sus pacientes víctimas de malos tratos In contact with the violence: the health care professionals and their patients victims of abuse

Revista Latino-Americana de Enfermagem, 2000
Utilizando-se de uma abordagem qualitativa, esse artigo delineia a percepção de profissionais de saúde, sobretudo pediatras, acerca da violência e sua responsabilidade em denunciar os casos que vivenciaram.
Marlene Braz, Maria Helena C.A. Cardoso
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source