Results 121 to 130 of about 40,507 (289)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Medical Assistance in Dying: Lessons for Australia from Canada

, 2017
Canada has recently witnessed dramatic changes in end-of-life law and policy. Most notably, we have moved from a prohibitive to a permissive regime with respect to medical assistance in dying (MAiD).
Downie, Jocelyn
core   +1 more source

Medical Assistance in Dying in Canada: An Ethical Analysis of Conscientious and Religious Objections

BioéthiqueOnline, 2016
Background: The Supreme Court of Canada (SCC) has ruled that the federal government is required to remove the provisions of the Criminal Code of Canada that prohibit medical assistance in dying (MAID).
Christie, Timothy, Sloan, John, Dahlgren, Dylan, Koning, Fred   +3 more
doaj  

Exploring multiple levels of suffering and suicide prevention in an era of emerging national legislations

Frontiers in Public Health
Access to assisted dying (variously called assisted suicide, euthanasia, and medical aid/assistance in dying) is increasingly available in many countries around the world.
Mark Goldblatt, Mark Goldblatt, Dolores Angela Castelli Dransart, Sylvie Lapierre, Sylvie Lapierre, Margda Waern, Margda Waern, Reinhard Lindner   +7 more
doaj   +1 more source

Morbid Matters: Medical Assistance in Dying in Federal Corrections

An ongoing problem of federal prisons in Canada continues to be deaths in custody. While prison suicides (i.e., dying by unnatural causes) and aging in prison (i.e., dying by natural causes) remain significant challenges, the legalization and ...
Jochelson, Richard, Trask, Brandon, Ranieri, Marisa, Corcoran, Lauren, Gacek, James   +4 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Medical assistance in dying and mental illness

Medicinska pomoć pri umiranju (MAiD, od engl. medical assistance in dying) uključuje eutanaziju i potpomognuto samoubojstvo, a obje opcije otvaraju važna etička, pravna i društvena pitanja o pravu pojedinca na autonomiju u odlučivanju o vlastitoj smrti ...
Ćelić, Ivan
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Terminal Illness. Assistance In Dying.

, 1991
TERMINAL ILLNESS. ASSISTANCE IN DYING. INITIATIVE STATUTE. Permits revocable written directive authorizing physician to terminate life in painless, humane and dignified manner by mentally competent adult after terminal illness diagnosed.

core   +2 more sources