Results 121 to 130 of about 116,165,088 (317)

End-of-Life Symptom Burden among Patients with Cancer Who Were Provided Medical Assistance in Dying (MAID): A Longitudinal Propensity-Score-Matched Cohort Study

Cancers
Simple Summary Cancer is the most common medical condition among Canadians who receive Medical Assistance in Dying (MAID). We aimed to evaluate if people who choose MAID have worse symptoms compared to those who do not. Using data from cancer patients in
K. B. Russell, C. Forbes, S. Qi, C. Link, Linda Watson, A. Deiure, Shuang Lu, James L. Silvius, B. Kelly, B. Bultz, Fiona S. M. Schulte   +10 more
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Personal Accountability of Medical Students in Medical Education [PDF]

, 2019
Producing graduates with sufficient practical competency is the main mission of every educational institution. Following the accreditation of the Korean Institute of Medical Education and Evaluation, medical schools have been stepping up efforts to ...
Korean Medical Education Review (의학교육논단)
core   +1 more source

Assisted death in eating disorders: a systematic review of cases and clinical rationales

Frontiers in Psychiatry
BackgroundAssisted dying for reasons solely related to an eating disorder (ED) has occurred in multiple countries, including those which restrict the practice to individuals with a terminal condition.
Chelsea Roff, Catherine Cook-Cottone
doaj   +1 more source

Exploring attitudes toward physician-assisted death in patients with life-limiting illnesses with varying experiences of palliative care: a pilot study

BMC Palliative Care, 2018
Background On February 6th, 2015, the Supreme Court of Canada ruled that competent adults suffering intolerably from a grievous and irremediable medical condition have the right to the assistance of a physician in ending their own lives, an act known as ...
Patricia Hizo-Abes, Lauren Siegel, Gil Schreier   +2 more
doaj   +1 more source

Perspectives of Canadian health leaders on the relationship between medical assistance in dying and palliative and end-of-life care services: a qualitative study

Canadian Medical Association Journal
Background: Medical assistance in dying (MAiD) was legalized in Canada in 2016, but coordination of MAiD and palliative and end-of-life care (PEOLC) services remains underdeveloped. We sought to understand the perspectives of health leaders across Canada
Gilla K. Shapiro, Eryn Tong, R. Nissim, Camilla Zimmermann, Sara Allin, Jennifer L. Gibson, Sharlane C L Lau, Madeline Li, Gary Rodin   +8 more
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Medical Assistance in Dying: Lessons for Australia from Canada [PDF]

, 2017
Canada has recently witnessed dramatic changes in end-of-life law and policy. Most notably, we have moved from a prohibitive to a permissive regime with respect to medical assistance in dying (MAiD).
Downie, Jocelyn
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Patient experiences with requests for medical assistance in dying

Canadian Family Physician Médecin de famille canadien
Objective To explore experiences of patients who have complex chronic conditions (CCCs), such as fibromyalgia and chronic fatigue syndrome, when they request medical assistance in dying (MAID) in Canada.
Clark Fruhstorfer, Michaela Kelly, Laura Spiegel, Peter Baylis, Justine Dembo, Ellen Wiebe   +5 more
semanticscholar   +1 more source