Results 161 to 170 of about 40,507 (289)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Medical Assistance in Dying in Canada: A Review for Canadian Dermatologists. [PDF]

J Cutan Med Surg
DeBiasio C, Green S, Kirchhof MG.
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Liver transplantation from donors following medical assistance in dying: a scoping review and retrospective cohort study. [PDF]

Can J Surg
Ganescu O, Solomon M, Chaudhury P, Paraskevas S, Hales L, Martel M, Metrakos P, Zogopoulos G, Tchervenkov J, Wong P, Barkun A, Barkun J.   +11 more
europepmc   +1 more source

What's the status of medical assistance in dying in Canada? [PDF]

CMAJ, 2023
Duong D, Vogel L.
europepmc   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Clinical Ethicists and Medical Assistance in Dying (MAiD): Possible Roles and Challenges. [PDF]

Bioethics
Finley-Roy V, Schildman J, Perron C, Bouthillier ME.   +3 more
europepmc   +1 more source

Communicating contentious issues in Canada: Analyzing media discourse of medical assistance in dying (MAID) [PDF]

, 2020
Taylor, Jessica
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Understanding the Factors Explaining the Growing Use of Medical Assistance in Dying in Québec: Protocol for an Interdisciplinary Mixed Methods and Multimethods Study. [PDF]

JMIR Res Protoc
Bouthillier MÈ, Marcoux I, Perron C, Gagnon B, Lussier D, Rouly G, Moreau M, Dorval M, Lessard S, Girard D, Bravo G, Hébert M, Giroux M, Lemyre S, Beaudin A, Bourque CJ, Soulières M, Lévesque M, Gupta M, Bourgeois-Guérin V, Lavoie D, Lavoie B, Plaisance A, Bernier L, Dupuis J.   +24 more
europepmc   +1 more source