Results 31 to 40 of about 481,644 (289)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky   +8 more
wiley   +1 more source

Antibiotic use for respiratory tract infections in nursing homes: a multicentre cross-sectional study

open access: yesFrontiers in Pharmacology
IntroductionTo evaluate the use of antibiotic treatment for respiratory tract infections (RTIs) in nursing homes in Spain, assess whether they were indicated based on current guidelines, and identify predictors of both use and inappropriate use of ...
Carl Llor   +21 more
doaj   +1 more source

Repeat prescribing of medications: a system-centred risk management model for primary care organisations [PDF]

open access: yes, 2017
Rationale, aims and objectives: Reducing preventable harm from repeat medication prescriptions is a patient safety priority worldwide. In the United Kingdom, repeat prescriptions items issued has doubled in the last 20 years from 5.8 to 13.3 items ...
Bartlett, Stephen   +5 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Audit of Bilateral Simultaneous Cochlear Implantation in Pediatric Population: South Indian Study

open access: yesTurkish Archives of Otorhinolaryngology, 2018
Objective: To conduct a medical audit of bilateral simultaneous cochlear implantation (CI) in patients with severe prelingual sensorineural hearing loss (SNHL).Methods: A medical audit of a tertiary care ear, nose, and throat center in Southern India was
Abha Kumari   +5 more
doaj   +1 more source

Desarrollo e implementación de una herramienta para la validación de cuentas médicas y gestión de glosas en el sector salud en Colombia

open access: yesMedicina U.P.B., 2018
Objetivo: la investigación pretende validar una herramienta de auditoría para la validación de cuentas médicas y la gestión de glosas en los procesos de auditoría con el fin de evaluar, controlar y mejorar los estándares de calidad y gestión en las ...
Tatiana Chavarría Chavarría
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Effective general practice: audit and feedback for the primary series of immunisations [PDF]

open access: yesJournal of Primary Health Care, 2014
INTRODUCTION: General practice immunisation audits do not always match the national rates recorded on the New Zealand (NZ) National Immunisation Register (NIR).
Reynolds G   +4 more
doaj  

The associations of factors with previous alcohol use in the Northern Territory compared to other states – an observational study

open access: yesAustralian and New Zealand Journal of Public Health, 2021
Background: Data on previous alcohol use in surgical patients who died in the Northern Territory (NT) are lacking and have important public health implications.
P. John Treacy   +4 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig   +9 more
wiley   +1 more source

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