Results 71 to 80 of about 4,460,235 (299)

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Clinical audit as a tool to optimize contracted private healthcare provision: Testing the waters in resource-deprived Greece

SAGE Open Medicine, 2019
Background and Aims: Clinical audit is applied to optimize clinical practice and quality of healthcare services while controlling for money spent, critically in resource-deprived settings.
Kyriakos Souliotis, Christina Golna, Vasiliki Mantzana, Sotirios Papaspyropoulos, Anastasios Koutsovasilis, Alexios Sotiropoulos   +5 more
doaj   +1 more source

Quantifying antibiotic use in typhoid fever in India: a cross-sectional analysis of private sector medical audit data, 2013-2015. [PDF]

BMJ Open, 2022
Fazaludeen Koya S, Hasan Farooqui H, Mehta A, Selvaraj S, Galea S.   +4 more
europepmc   +1 more source

A review of auditing techniques for the Unified Medical Language System [PDF]

, 2020
Ling Zheng, Zhe He, Duo Wei, Vipina K. Keloth, Jungwei Fan, Luke Lindemann, Xinxin Zhu, James J. Cimino, Yehoshua Perl   +8 more
openalex   +1 more source

HPB P36 Good Medical Practice: Patient's right to the information - An audit of the patient's understanding and satisfaction with the information provided to the patients with acute pancreatitis [PDF]

, 2023
Zeeshan Khawaja, Zohaib Jamal, Nowera Zafar, Naqqash Adnan   +3 more
openalex   +1 more source

Two‐Dimensional Alloying at the Iron‐Copper Interface in Steel Driven by Magnetic Friedel Oscillations

Advanced Science, EarlyView.
The interlayer magnetic couplings (left) and the changes of atomic‐layer‐averaged electron density (right) for Fe and Cu sides near the sharp and diffuse Fe/Cu (001) interfaces reveal that magnetic Friedel oscillations at Fe/Cu interfaces in steel drive atomic‐scale 2D alloying, resolving the long‐standing paradox of high Fe content in Cu precipitates.
Wen‐Qiang Xie, Jin‐Li Cao, Jian‐Long Kou, Wen Tong Geng   +3 more
wiley   +1 more source

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

Advanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang, Yuming Wang, Zihao Chen, Erji Gao, Liang Guo, Juanjuan Li, Siqiang Zheng, Jiaoyu Yi, Zhe‐Sheng Chen, Bo Tao   +9 more
wiley   +1 more source

Congenital Hypothyroidism: An Audit and Study of Different Cord Blood Screening TSH Values in a Tertiary Medical Centre in Malaysia [PDF]

, 2015
Sze Lyn Jeanne Wong, Muhammad Yazid Jalaludin, Azriyanti Anuar Zaini, Nurshadia Samingan, Fatimah Harun   +4 more
openalex   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

Advanced Science, EarlyView.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam, Ana Esmeralda Gomez Martinez, Alison Su, Anna Fomitcheva‐Khartchenko, Xin Wang, Md Nazibul Islam, Paul Lum, Amy Elizabeth Herr   +7 more
wiley   +1 more source