Results 41 to 50 of about 2,847,760 (264)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Domesticating Ai in Medical Diagnosis

Technology in Society, 2023
We consider the anticipated adoption of Artificial Intelligence (AI) in medical diagnosis. We examine how seemingly compelling claims are tested as AI tools move into real-world settings and discuss how analysts can develop effective understandings in novel and rapidly changing settings.
Robin Williams, Stuart Anderson, Kathrin Cresswell, Mari Serine Kannelønning, Hajar Mozaffar, Xiao Yang   +5 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Similarity Measures of Spherical Fuzzy Sets Based on Cosine Function and Their Applications

IEEE Access, 2019
In this paper, we defined ten similarity measures between spherical fuzzy sets (SFSs) based on the cosine function by considering the degree of positive-membership, degree of neutral-membership, degree of non-membership and degree of refusual-membership ...
Guiwu Wei, Jie Wang, Mao Lu, Jiang Wu, Cun Wei   +4 more
doaj   +1 more source

Deep Learning Based Fast Screening Approach on Ultrasound Images for Thyroid Nodules Diagnosis

Diagnostics, 2021
Thyroid nodules are widespread in the United States and the rest of the world, with a prevalence ranging from 19 to 68%. The problem with nodules is whether they are malignant or benign.
Hafiz Abbad Ur Rehman, Chyi-Yeu Lin, Shun-Feng Su   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

An Ensemble Model for Fundus Images to Aid in Age-Related Macular Degeneration Grading

Diagnostics
Background: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly population. Periodic examinations through fundus image analysis are paramount for early diagnosis and adequate treatment.
Roberto Romero-Oraá, María Herrero-Tudela, María Isabel López, Roberto Hornero, Pere Romero-Aroca, María García   +5 more
doaj   +1 more source

A ‘medical’ diagnosis in the trauma clinic [PDF]

BMJ Case Reports, 2013
A previously healthy 27-year-old Nepalese man presented with a history of direct low-impact direct trauma to the left leg. An x-ray was performed in a private hospital and he was referred to our emergency department for the management of a possible foreign body in the left leg.
Kosar, Hussain, Firas Jafar Kareem, AlNajjar, Mohammad Javad, Ahmad, Sahar, Hussain   +3 more
openaire   +2 more sources