Results 91 to 100 of about 7,713,906 (370)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Advance care planning in Norwegian nursing homes – limited awareness of the residents’ preferences and values? A qualitative study

BMC Geriatrics, 2019
Background 52% of all deaths in Norway occur in nursing homes. Still advance care planning (ACP) is scarce and heterogeneous. To improve the implementation and practice of ACP in nursing homes, knowledge about health care professionals’ views on ACP is ...
Lisbeth Thoresen, Reidar Pedersen, Lillian Lillemoen, Elisabeth Gjerberg, Reidun Førde   +4 more
doaj   +1 more source

What is a good health check? An interview study of health check providers’ views and practices

BMC Medical Ethics, 2017
Background Health checks identify (risk factors for) disease in people without symptoms. They may be offered by the government through population screenings and by other providers to individual users as ‘personal health checks’.
Yrrah H. Stol, Eva C. A. Asscher, Maartje H. N. Schermer   +2 more
doaj   +1 more source

Medical conspiracy theories: cognitive science and implications for ethics

Medicine, Health care and Philosophy, 2020
Although recent trends in politics and media make it appear that conspiracy theories are on the rise, in fact they have always been present, probably because they are sustained by natural dispositions of the human brain.
Gabriel E Andrade
semanticscholar   +1 more source

Allies Not Adversaries: Teaching Collaboration to the Next Generation of Doctors and Lawyers to Address Social Inequality [PDF]

, 2008
Recent reports from the Carnegie Foundation for the Advancement of Teaching, as well as from other medical and legal educators, stress that professional training of doctors and lawyers focuses too narrowly on knowledge-based learning, and not enough on ...
Tyler, Elizabeth Tobin
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Development of Strategies for Advancement of Medical Ethics Education in Isfahan University of Medical Sciences [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2013
Introduction: Medical ethics is an analytical attempt that deals with various aspects of ethical decision making in medicine. According to the importance and goals of medical ethics, this study is an endeavor to evaluate strengths and weaknesses ...
Parisa Malekahmadi, Parinaz parsa
doaj  

Moving Beyond Mismatch [PDF]

, 2019
In this peer commentary on Maura Priest's "Transgender Children and the Right to Transition: Medical Ethics When Parents Mean Well but Cause Harm", I argue against the "mismatch" model of trans identity. On this model, which is prevalent in institutional
Dembroff, Robin
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

A Study of the Components of Medical Ethics in Ancient Persian Literature and Its Comparison with Modern Medical Ethics [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: Findings from ancient Persian literary texts indicate that the issue of professional medical ethics and the correct and logical relationship between a doctor and a patient has not been hidden from the eyes of writers and poets.
A Ebrahimi Mehr
doaj