Results 131 to 140 of about 7,285,416 (318)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Application to the Dilemma Discussion Program: Ethics and Character Education for Medical Students
, 2009 The current medical practices in Korea have raised many new ethical issues. The current education system in med- ical colleges, however, is finding it difficult to cope with these rapidly arising medical issues.
연세대학교 의과대학
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Autonomy, problem-based learning and the teaching of medical ethics
, 1995 Autonomy has been the central principle underpinning changes which have affected the practice of medicine in recent years. Medical education is undergoing changes as well, many of which are underpinned, at least implicitly, by increasing concern for ...
Parker, M., Parker, Malcolm
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The Significance Of The Hippocratic Oath To The Principles Of Contemporary Medical Ethics
, 2019 Настоящата статия има за цел да изследва значението на Хипократовата клетва и нейните модификации за съвременната медицинска етика. По тази причина се анализират на първо място принципите на клетвата и влиянието й през вековете, а в последствие ...
Slavova, Veselina; Training and Research Sector of Medical Laboratory Assistant, Medical College, Medical University of Varna
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2012 Understanding dental ethics as a field separate from its much better known counterpart, medical ethics, is a relatively new, but necessary approach in bioethics.
GÖRKEY, ŞEFİK, SERT, GÜRKAN
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Teaching Medical Ethics in Other Countries
, 1985 A survey is provided of the status of the teaching of medical ethics and bioethics in North American and Western European countries other than Great Britain.
Wolstenholme, Gordon
core +1 more source