Results 171 to 180 of about 1,273,127 (279)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Basic concepts of medical genetics formal genetics, Part 3

Egyptian Journal of Medical Human Genetics, 2014
Mohammad Saad Zaghloul Salem
doaj   +1 more source

Medical genetics needs assessment: An online cross-sectional survey from Nepal. [PDF]

Genet Med Open
Gyawali P, Shrestha B, Beharry K, Agarwal G, Quinonez SC.   +4 more
europepmc   +1 more source

Telemedicine - chances and challenges for medical genetics in Germany. [PDF]

Med Genet, 2021
Tecklenburg J.
europepmc   +1 more source

Medical Genetics at a Glance, 2nd edn

, 2011
Lisa J. Walker
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Basic concepts of medical genetics, formal genetics, Part 1

Egyptian Journal of Medical Human Genetics, 2014
Mohammad Saad Zaghloul Salem
doaj   +1 more source

European training requirements for the specialty of medical genetics. [PDF]

Eur J Hum Genet
Moog U, Berg J, Kerr S, Turnpenny PD, Verloes A, Working Group ETR for Medical Genetics, Zschocke J.   +6 more
europepmc   +1 more source

Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med, 2023
Hanson H, Astiazaran-Symonds E, Amendola LM, Balmaña J, Foulkes WD, James P, Klugman S, Ngeow J, Schmutzler R, Voian N, Wick MJ, Pal T, Tischkowitz M, Stewart DR, ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net.   +14 more
europepmc   +1 more source

Medical genetics: advances in brief: Tetrahydrobiopterin - Basic Biochemistry and Role in Human Disease. [PDF]

, 1998
A F Heeley
openalex   +1 more source