Results 171 to 180 of about 1,278,547 (317)

Principles and Practice of Medical Genetics [PDF]

, 1984
M. S. Pembrey
openalex   +1 more source

Reminiscence of a Teacher of Medical Genetics — E. M. Nicholls [PDF]

, 2020
Alan E. Stark
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Efficacy of a medical genetics rotation during pediatric training [PDF]

, 2015
Joanne Nguyen, Jennifer Lemons, Sharon S. Crandell, Hope Northrup   +3 more
openalex   +1 more source

Scoping review and classification of deep learning in medical genetics

, 2022
Suzanna E. Ledgister Hanchard, Michelle C. Dwyer, Simon Liu, Ping Hu, Cedrik Tekendo‐Ngongang, Rebekah L. Waikel, Dat Duong, Benjamin D. Solomon   +7 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Disrupting Essentialism in Medical Genetics Education. [PDF]

Med Sci Educ, 2022
Gingell G, Bergemann AD.
europepmc   +1 more source

Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡ [PDF]

, 2017
Joyce Harper, Kristiina Aittomäki, Pascal Borry, Martina C. Cornel, Guido de Wert, Wybo Dondorp, Joep Geraedts, Luca Gianaroli, K. Ketterson, I. Liebærs, Kersti Lundin, Heidi Mertes, Michael A. Morris, Guido Pennings, Karen Sermon, Claudia Spits, Sirpa Soini, Aafke P.A. van Montfoort, Anna Veiga, Joris Vermeesch, Stéphane Viville, Milan Maçek, on behalf of the European Society of Human Reproduction and Embryology and European Society of Human Genetics   +22 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Medical genetics [PDF]

BMJ, 1977
openaire   +2 more sources