Results 221 to 230 of about 1,221,619 (355)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Single center experience developing sustainable genetics clinical care: a model to address workforce challenges in medical genetics. [PDF]

Curr Opin Pediatr
Kinney A, Dalton SA, McCarrier J, Basel D.   +3 more
europepmc   +1 more source

Medical genetics: advances in brief: Mitochondrial encephalopathies with the mutation of the mitochondrial tRNALeu(UUR) [PDF]

, 1992
David Fitzpatrick
openalex   +1 more source

Medical genetics in Israel. [PDF]

Journal of Medical Genetics, 1989
B Bonne-Tamir, R Voss, G Barkai, M B Katznelson, R. M. Goodman, Y Shiloh, A Adam, Gideon Bach, B Goldman, B Padeh   +9 more
openaire   +3 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

College of American Pathologists (CAP)/American College of Medical Genetics and Genomics (ACMG) proficiency testing for urinary glycosaminoglycan analysis: A summary of performance. [PDF]

Genet Med Open
Cusmano-Ozog K, Matern D, Long T, Longo N, Young S.   +4 more
europepmc   +1 more source

Medical Genetics, Genomics and Bioinformatics Aid in Understanding Molecular Mechanisms of Human Diseases. [PDF]

Int J Mol Sci, 2021
Orlov YL, Anashkina AA, Klimontov VV, Baranova AV.   +3 more
europepmc   +1 more source

Medical genetics: advances in brief: Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation [PDF]

, 1993
Nalin Thakker
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Trainee perspectives of COVID-19 impact on medical genetics education. [PDF]

Genet Med, 2021
Pritchard AB, Sloan-Heggen C, Keegan CE, Quinonez SC.   +3 more
europepmc   +1 more source