Results 241 to 250 of about 1,221,619 (355)

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Medical genetics: advances in brief: The fish odour syndrome: biochemical, familial, and clinical aspects [PDF]

, 1994
A M Norman
openalex   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Trofinetide approved for children and adults with Rett syndrome (RTT): A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med Open
Selvam P, Mares Beltrán CF, Sen K, Morales Corado A, ACMG Therapeutics Committee5∗documents@acmg.net.   +4 more
europepmc   +1 more source

Diversity, inclusion and equity in medical genetics: The time is now. [PDF]

Am J Med Genet A, 2020
Quintero-Rivera F, Hisama FM.
europepmc   +1 more source

Correction: Martini, A.; Cassina, M. Victor A. McKusick, the "Father of Medical Genetics". Audiol. Res. 2021, 11, 636-638. [PDF]

Audiol Res, 2022
Martini A, Cassina M.
europepmc   +1 more source

Genetics in Jeopardy: The Diagnosis and Treatment of Chronic Disease in an Undergraduate Medical Course-A Case Report

, 1986
Richard G. Tiberius, R. Gold
openalex   +1 more source

Medical genetics: advances in brief: Integration of human -satellite DNA into simian chromosomes: centromere protein binding and disruption of normal chromosome segregation [PDF]

, 1992
Nalin Thakker
openalex   +1 more source

Medical genetics in Romania. [PDF]

Journal of Medical Genetics, 1990
C Maximilian, M Covic, G Benga, D Stefanescu, M Bembea   +4 more
openaire   +3 more sources

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source