Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel +10 more
wiley +1 more source
Infection-Independent Effect of the COVID-19 Pandemic on Diabetes and Cardiovascular Disease Mortality: An Illinois Vital Records System Analysis, 2019-2021. [PDF]
Niederhauser JE, Harper PC, Pittman P.
europepmc +1 more source
ABSTRACT Ravulizumab, a second‐generation complement component 5 inhibitor (C5i) derived from eculizumab, with improved pharmacokinetics, is the current standard‐of‐care treatment for patients with paroxysmal nocturnal hemoglobinuria (PNH), where available.
Alexander Röth +8 more
wiley +1 more source
Intersectional dimensions of stigma in neglected tropical diseases: a systematic review of evidence and implications for equity-based health policy. [PDF]
Dejene K, Kühner S.
europepmc +1 more source
Epidemiology of Cancer‐Associated Venous Thromboembolism Across the United States
ABSTRACT Prior epidemiological studies on cancer‐associated venous thromboembolism (VTE) were limited by homogenous patient populations. We leverage Cosmos, a collaborative dataset of Epic electronic health record systems, to conduct an updated evaluation of cancer‐associated VTE in the United States (US).
Barbara D. Lam +7 more
wiley +1 more source
Could lessons from medical research ethics inform better conversations and governance for climate engineering research. [PDF]
Fitzgerald SD +3 more
europepmc +1 more source
ABSTRACT Renal impairment (RI), defined as estimated glomerular filtration rate less than 60 mL/min with or without the need for dialysis, is a frequent and severe complication in patients with relapsed/refractory multiple myeloma (RRMM), as it can affect patient prognosis, drug metabolism and treatment options.
Ioannis Ntanasis‐Stathopoulos +7 more
wiley +1 more source
When Geography Dictates Care: The Rural Gastroenterology Challenge. [PDF]
Bahirwani J +3 more
europepmc +1 more source
ABSTRACT Background A causal association between occupational asbestos exposure and lung disease, including pneumoconiosis and mesothelioma, is well established. Elevated mortality among former asbestos miners is expected. However, large‐scale South African studies examining all‐cause mortality in this population are lacking.
Yumna Williams‐Mohamed +3 more
wiley +1 more source
Demographic and Geographic Heterogeneity in Tongue Cancer Mortality in the United States, 1999-2020. [PDF]
Gong A, Ge H, Yang C.
europepmc +1 more source

