Context-based task ontologies for clinical guidelines [PDF]
, 2004 Evidence-based medicine relies on the execution of clinical practice guidelines and protocols. A great deal of of effort has been invested in the development of various tools which automate the representation and execution of the recommendations ...
Ciccarese, Paolo +3 more
core
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
ACTIVITIES OF NURSE PRACTITIONERS AS IDENTIFIED BY MEDICAL DIRECTORS OF UNIVERSITY STUDENT HEALTH SERVICES [PDF]
, 1979 University health services play a very important role in the general health, performance, and well-being of the students, the university itself, and the community.
Gottlieb, Miriam Lee +1 more
core +1 more source
Comparison of the effect of 360° versus two-dimensional virtual reality video on history taking and physical examination skills learning among undergraduate medical students: a randomized controlled trial [PDF]
, 2022 Yi‐Ping Chao +10 more
openalex +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Improving diagnostic accuracy using a clinical diagnostic support system for medical students during history-taking: a randomized clinical trial [PDF]
, 2023 Yasutaka Yanagita +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source
Diagnostic unreliability between research and clinical practice in psychiatry still matters: a call for discussion about medical history taking and diagnostic interview basic principles [PDF]
, 2023 Helio G. Rocha Neto +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
wiley +1 more source