Results 71 to 80 of about 1,372,549 (269)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Novel Artificial-Intelligence-Based Approach for Automatic Assessment of Retinal Disease Images Using Multi-View Deep-Broad Learning Network

IEEE Access
Retinal disease detection and diagnosis relying solely on artificial retinal diseases will put great pressure on doctors and increase the rate of misdiagnosis.
Ao Zhang, Xin Qian, Chengcheng Xu, Jie Zhang   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption

Fluids and Barriers of the CNS
Traditionally, cerebrospinal fluid (CSF) is believed to exit the brain via arachnoid villi, being absorbed into the superior sagittal sinus (SSS), with a net flow towards these exit sites driven by constant CSF turnover.
E. C. van der Voort, M. C. E. van der Plas, M. W. J. M. Gosselink, J. J. M. Zwanenburg   +3 more
doaj   +1 more source

3D Vessel Centerline Extraction via Vascular Morphology Driven Adaptive Deep Reinforcement Tracking

IEEE Access
Accurate vessel centerline extraction in medical images has important clinical value for preoperative diagnosis and intraoperative intervention of vascular diseases.
Jingliang Zhao
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Secure Medical Image Sharing: Technologies, Watermarking Insights, and Open Issues

IEEE Access
With the growth of the Internet, medical documents have become widely used by healthcare professionals. Secure transmission and management of medical images are essential to enable collaboration while protecting sensitive patient information.
Sawsan D. Mahmood, Fadoua Drira, Hussain Falih Mahdi, Adel M. Alimi   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Super resolution reconstruction for medical image based on adaptive multi-dictionary learning and structural self-similarity

Computer Assisted Surgery, 2019
To improve the quality of the super-resolution (SR) reconstructed medical images, an improved adaptive multi-dictionary learning method is proposed, which uses the combined information of medical image itself and the natural images database.
Fang Zhang, Yue Wu, Zhitao Xiao, Lei Geng, Jun Wu, Jia Wen, Wen Wang, Ping Liu   +7 more
doaj   +1 more source