Results 161 to 170 of about 17,816,512 (303)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Review of Deep Learning Methods for Multimodal Medical Image Fusion. [PDF]

Sensors (Basel)
Shi Y, Rigou M.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Medical College of South Carolina, circa 1854

This glass lantern slide features a black and white drawing of the original Medical College of South Carolina building, circa ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Medical College Hospital, May 1953

, 1953
This glass lantern slide features an aerial view of the Medical College of South Carolina Hospital under construction in May ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Intentional Degradation for Stabilizing Residual Learning in Coarse-to-Fine Medical Image Refinement. [PDF]

J Imaging
Kim M, Lee SA, Kim H, Park S, Park J, Yoon J, Cho YS, Hur J, Kym D.   +8 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Medical College Hospital bridge

This glass lantern slide features a ground view of the bridge extending from the Medical College of South Carolina ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Parametric Physically Grounded Rendering of Otoscopic Morphology for Synthetic Medical Image Generation. [PDF]

J Imaging
Keustermans W, Barrie D, Van der Jeught S.   +2 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source