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Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source

Multiscale feature fusion for few-shot medical image learning with fisher information-driven layer selection. [PDF]

Vis Comput Ind Biomed Art
Zhang K, Peng Y, Pang B, Chen X.
europepmc +1 more source

EXPRESSION OF CONCERN: DIMP53‐1: A Novel Small‐Molecule Dual Inhibitor of p53–MDM2/X Interactions with Multifunctional p53‐Dependent Anticancer Properties

Molecular Oncology, EarlyView.
wiley +1 more source

Segment anything model guided dual-mask framework for anatomically faithful medical image translation. [PDF]

Sci Rep
Lee H, Jo Y, Hong I, Kim J, Park S.
europepmc +1 more source

A hybrid CNN-Transformer network integrating multiscale spatially detailed features for medical image segmentation. [PDF]

PLoS One
Li B, Zhou W, Li H.
europepmc +1 more source

Development and evaluation of a multistage transfer learning framework for robust medical image analysis. [PDF]