Results 101 to 110 of about 18,046,440 (303)

Medical College court, 1950

, 1950
This glass lantern slide features an aerial view of the Medical College of the State of South Carolina court in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Combined Loss-driven Framework for Automated Parotid Segmentation in Head-and-Neck Computed Tomography

Journal of Medical Physics
Purpose: This study presents a deep learning framework for automatic parotid segmentation using three-dimensional (3D) U-Net and attention-augmented 3D U-Net architectures trained with a novel combined loss function tailored for anatomical accuracy and ...
Aryan Tyagi, Anuj Kumar, Sandeep Singh, Mohini Manav, Soniya Pal   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Medical Center campus, 1953

, 1953
This glass lantern slide features a map of the Medical Colleg of South Carolina Medical Center campus in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Automated Computer-Assisted Diagnosis of Pleural Effusion in Chest X-Rays via Deep Learning

Diagnostics
Background/Objectives: Pleural effusion is a common pulmonary condition that, if left untreated, may lead to respiratory distress and severe complications.
Ya-Yun Huang, Yu-Ching Lin, Sung-Hsin Tsai, Tsun-Kuang Chi, Tsung-Yi Chen, Shih-Wei Chung, Kuo-Chen Li, Wei-Chen Tu, Patricia Angela R. Abu, Chih-Cheng Chen   +9 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Medical Center, 1950

, 1950
This glass lantern slide features an aerial view of the Medical Center building of the Medical College of the State of South Carolina in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source