Results 61 to 70 of about 1,481,089 (317)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Deep learning-based magnetic resonance image segmentation technique for application to glioma
Frontiers in Medicine, 2023 IntroductionBrain glioma segmentation is a critical task for medical diagnosis, monitoring, and treatment planning.DiscussionAlthough deep learning-based fully convolutional neural networks have shown promising results in this field, their unstable ...
Bing Wan +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Applied Sciences, 2020 Malignant lesions are a huge threat to human health and have a high mortality rate. Locating the contour of organs is a preparation step, and it helps doctors diagnose correctly.
Chen Li, Wei Chen, Yusong Tan
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Automatic COVID-19 and Common-Acquired Pneumonia Diagnosis Using Chest CT Scans
Bioengineering, 2023 Even with over 80% of the population being vaccinated against COVID-19, the disease continues to claim victims. Therefore, it is crucial to have a secure Computer-Aided Diagnostic system that can assist in identifying COVID-19 and determining the ...
Pedro Crosara Motta +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
European Radiology ExperimentalObjective Primary sclerosing cholangitis (PSC) is a rare fibroinflammatory hepatobiliary disease with a highly variable clinical course. Identifying patients at risk for poor outcomes remains challenging. Magnetic resonance imaging (MRI)-based approaches
Wolf C. Bartholomä +7 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Active contours based on weighted gradient vector flow and balloon forces for medical image segmentation [PDF]
, 2014 Active contours, or snakes, have been widely used for image segmentation purposes. However, high noise sensitivity and poor performance over weak edges are the most acute issues that hinder the segmentation accuracy of these curves, particularly in ...
Victor Sanchez +5 more
core +1 more source